Immunoregulatory networks in human Chagas disease.
Immunoregulatory networks in human Chagas disease.
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DOI：
10.1111/pim.12107
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发表时间：
2014-08
影响因子：
2.2
通讯作者：
Gollob KJ
中科院分区：
文献类型：
--
作者：
Dutra WO;Menezes CA;Magalhães LM;Gollob KJ
恰加斯病是由克氏锥虫感染引起的，在整个拉丁美洲都是地方病。由于人口迁移的增加，恰加斯病已经在世界范围内传播，现在不仅在流行国家被认为是一个健康问题。虽然大多数慢性感染者仍然没有症状，但大约30%的患者会发展为潜在的致命心肌病。心脏病理的建立和维持的确切机制尚不清楚。然而，有一致的证据表明，免疫调节细胞因子对协调免疫反应至关重要，从而影响疾病的发展或控制。虽然无症状(不确定)的形式代表了宿主和寄生虫之间的平衡状态，但心脏形式的建立代表了这种平衡的丧失。对几项研究数据的分析导致了一种假设，即不确定的形式与抗炎细胞因子谱相关，以IL-10的高表达为代表，而心脏形式与与IL-10相关的高水平的干扰素-γ和肿瘤坏死因子-α的产生有关，从而导致炎症谱。在这里，我们讨论可能影响疾病结局的免疫调节事件，以及影响这些复杂免疫调节网络建立的机制。
Chagas disease, caused by the infection with Trypanosoma cruzi, is endemic in all Latin America. Due to the increase in population migration, Chagas disease has spread worldwide and is now considered a health issue not only in endemic countries. While most chronically infected individuals remain asymptomatic, approximately 30% of the patients develop a potentially deadly cardiomyopathy. The exact mechanisms that underlie the establishment and maintenance of the cardiac pathology are not clear. However, there is consistent evidence that immunoregulatory cytokines are critical for orchestrating the immune response and, thus, influence disease development or control. While the asymptomatic (indeterminate) form represents a state of balance between the host and the parasite, the establishment of the cardiac form represents the loss of this balance. Analysis of data obtained from several studies have led to the hypothesis that the indeterminate form is associated with an anti-inflammatory cytokine profile, represented by high expression of IL-10, while cardiac form is associated with a high production of IFN-gamma and TNF-alpha in relation to IL-10, leading to an inflammatory profile. Here, we discuss the immunoregulatory events that might influence disease outcome, as well as the mechanisms that influence the establishment of these complex immunoregulatory networks.
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影响因子：
3.3
作者：
Corrêa-De-Santana, E;Paez-Pereda, M;Savino, W
通讯作者：
Savino, W
影响因子：
4
作者：
Brisse, S;Verhoef, J;Tibayrenc, M
通讯作者：
Tibayrenc, M
影响因子：
2.7
作者：
Cruz-Robles, D;Reyes, PA;Vargas-Alarcón, G
通讯作者：
Vargas-Alarcón, G
影响因子：
3.3
作者：
Añez, N;Crisante, G;Teixeira, MMG
通讯作者：
Teixeira, MMG
影响因子：
3.1
作者：
da Silveira, A. B. M.;Reis, D. D'Avila;Furness, J. B.
通讯作者：
Furness, J. B.