Association between constipation and the development of asthma: a meta-analysis.
Association between constipation and the development of asthma: a meta-analysis.
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DOI：
10.1186/s13223-022-00708-9
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发表时间：
2022-08-08
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影响因子：
--
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--
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据推测，哮喘与喘息或哮喘的风险增加有关。然而，这种关系仍然是一个争论的主题。我们进行了这项荟萃分析，以评估便秘是否影响喘息/哮喘的风险。PubMed、Embase和Web of Science系统检索了1955年至2022年1月期间发表的研究。两名评审员独立提取数据并评估每项研究的质量。使用固定效应模型或随机效应模型（视情况而定）汇总结果。本荟萃分析共纳入了3篇符合标准的原始文献（178，661例受试者）。哮喘/喘息的发生与哮喘/喘息的发生有关（RR = 2.02，95% CI = 1.24-3.29，P < 0.01）。荟萃分析表明便秘与随后发生的喘息/哮喘之间存在关联。需要设计良好和高度标准化的前瞻性研究，充分解决潜在的混杂因素的关注，以验证我们目前的荟萃分析中确定的风险。在线版本包含补充材料，可通过10.1186/s13223-022-00708-9获得。
Constipation has been hypothesized to be associated with the increased risk of wheezing or asthma. However, the relation remains a subject of debate. We conducted this meta-analysis to assess whether constipation influences the risk of wheezing/asthma. PubMed, Embase, and Web of Science were systematically searched for studies published between 1955 and January 2022. Two reviewers independently extracted data and assessed the quality of each study. Results were pooled using fixed-effects models or random-effects models as appropriate. In total, 3 original articles with 178,661 participants, which met the criteria, were included in this meta-analysis. Constipation was associated with an increased risk of wheezing/asthma in later life (RR = 2.02, 95% CI = 1.24–3.29, P < 0.01). The meta-analysis suggests an association between constipation and the subsequent development of wheezing/asthma. Well-designed and highly standardized prospective studies that adequately address concerns for potential confounding factors are required to validate the risk identified in our current meta-analysis. The online version contains supplementary material available at 10.1186/s13223-022-00708-9.
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影响因子：
7
作者：
Huedo-Medina, Tania B.;Sanchez-Meca, Julio;Botella, Juan
通讯作者：
Botella, Juan
影响因子：
4.3
作者：
Leander, Mai;Cronqvist, Agneta;Rask-Andersen, Anna
通讯作者：
Rask-Andersen, Anna
影响因子：
6.1
作者：
Wallis, RM;Napier, CM
通讯作者：
Napier, CM
DOI：
10.5588/ijtld.14.0170
发表时间：
2014-11-01
影响因子：
4
作者：
Asher, I.;Pearce, N.
通讯作者：
Pearce, N.
影响因子：
7.2
作者：
IntHout, Joanna;Ioannidis, John P. A.;Goeman, Jelle J.
通讯作者：
Goeman, Jelle J.