Adverse perinatal outcomes and its associated factors among adult and advanced maternal age pregnancy in Northwest Ethiopia.
Adverse perinatal outcomes and its associated factors among adult and advanced maternal age pregnancy in Northwest Ethiopia.
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DOI：
10.1038/s41598-021-93613-x
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发表时间：
2021-07-07
影响因子：
4.6
通讯作者：
Lake S
中科院分区：
文献类型：
--
作者：
Getaneh T;Asres A;Hiyaru T;Lake S
尽管需要降低新生儿死亡率以实现2030年可持续发展目标，但高龄产妇仍然是不同不良围产期结局的一个独立和重大风险因素，进而导致新生儿发病率和死亡率。在埃塞俄比亚，研究证实高龄产妇是围产期不良结局的一个重要因素，但解决或估计其不良围产期结局的研究有限，报告的结果不一致，特别是在研究领域没有进行研究。因此，本研究旨在比较埃塞俄比亚西北部成年和高龄孕妇的不良围产期结局及其相关因素。在埃塞俄比亚西北部的Awi区公立医院进行了比较横断面研究。采用系统随机抽样方法，抽取348例成年孕妇和176例高龄孕妇。采用结构式问卷调查收集资料。使用社会科学统计软件包第25版分析收集的数据。二元和多元Logistic回归拟合，以评估不良围产期结局和解释变量之间的关联。P值小于0.05用于声明统计学显著性。高龄妇女（29.1%）与成年妇女（14.5%）相比，围产期结局不良。高龄产妇的低出生体重儿、早产儿和低Apgar评分的比例也明显高于高龄产妇。高龄产妇围产期综合不良结局的发生率高于成年产妇（AOR 2.01，95% CI 1.06，3.79）。未接受正规教育（AOR 2.75，95% CI 1.27，5.95）、生育间隔短（AOR 2.25，95% CI 1.07，4.73）和妊娠期并发症（AOR 2.12，95% CI 1.10，4.10）也是与不良围产儿结局显著相关的因素。与成年妇女相比，高龄产妇围产期不良结局的风险更高。母亲文盲、生育间隔短和妊娠期并发症也与不良围产期结局显著相关。建议提供平等教育、计划生育和围产期护理（包括早期发现和处理并发症）。
Even though reduction of neonatal mortality is needed to achieve Sustainable Development Goals 2030, advanced maternal age is still an independent and a substantial risk factor for different adverse perinatal outcomes, in turn causes neonatal morbidity and mortality. In Ethiopia, research has validated that advanced maternal age is a significant factor in adverse perinatal outcomes, but researches which addressed or estimated its adverse perinatal outcomes are limited, reported inconsistent result and specifically no study was done in the study area. Therefore, this study was aimed to compare adverse perinatal outcomes and its associated factors among women with adult and advanced maternal age pregnancy in Northwest Ethiopia. Comparative cross-sectional study was conducted in Awi Zone, public hospitals, Northwest Ethiopia. Systematic random sampling was employed to select 348 adult and 176 advanced aged pregnant women. Structured questionnaire were used to collect the data. The collected data were analyzed using Statistical Package for the Social Sciences version 25. Binary and multivariate logistic regressions were fitted to assess the association between adverse perinatal outcomes and explanatory variables. P-value less than 0.05 was used to declare statistical significance. Significant percentage of advanced aged women (29.1%) had adverse perinatal outcomes compared to (14.5%) adult aged women. Similarly, proportion low birth weight, preterm birth and low Apgar score were significantly higher among advanced maternal age. The odds of composite adverse perinatal outcomes were higher among advanced maternal age women when compared to adult aged women (AOR 2.01, 95% CI 1.06, 3.79). No formal education (AOR 2.75, 95% CI 1.27, 5.95), short birth interval (AOR 2.25, 95% CI 1.07, 4.73) and complications during pregnancy (AOR 2.12, 95% CI 1.10, 4.10) were also factors significantly associated with adverse perinatal outcomes. Being advanced maternal age is at higher risk for adverse perinatal outcomes compared to adult aged women. Maternal illiteracy, short birth interval and complications during pregnancy were also significantly associated with adverse perinatal outcomes. Access of equal education, provision of family planning and perinatal care (including early detection and management of complication) is recommended.
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