Unveiling the role of novel biogenic functionalized CuFe hybrid nanocomposites in boosting anticancer, antimicrobial and biosorption activities.
Unveiling the role of novel biogenic functionalized CuFe hybrid nanocomposites in boosting anticancer, antimicrobial and biosorption activities.
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DOI：
10.1038/s41598-021-87363-z
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发表时间：
2021-04-08
影响因子：
4.6
通讯作者：
Abd-El-Haleem D
中科院分区：
文献类型：
--
作者：
Eltarahony M;Abu-Serie M;Hamad H;Zaki S;Abd-El-Haleem D
寻求生态友好和生物相容的纳米粒子(NPs)是科学界和应用技术领域迫切需要解决的问题，它压缩了合成路线。首次利用链霉菌通过同时还原铜和铁盐的策略，获得了一条合成功能化CuFe杂化纳米复合材料(FCFNCs)的简单途径。对FCFNCs作为抗癌剂、抗菌剂和染料生物吸附剂的适宜性进行了医学和环境评价。X射线衍射仪、能谱分析、元素图谱、红外光谱、紫外可见光谱、透射电子显微镜和ζ-电位等表征结果表明，FCFNCs形成了球状的链状结构(37 ± 2.2 nm)，由蛋白质基团形成的自功能化纳米复合材料具有较高的稳定性(− 为26.2 mV)。作为一种抗癌药物，FCFNC对Caco-2、HepG-2、MCF7和PC-3癌细胞的凋亡率最高(>； )，IC50IC50为17.21g/mLFCFNCs对P53和Caspase3表达的上调幅度最大，Ki-67的表达水平最低，与功能化铜纳米粒(FCNPs)和铁纳米粒(FFNPs)相比，FCFNCs对Caco-2、Hep-2、MCF7和PC-3癌细胞的凋亡率最高(>； )，P53和Caspase3的表达上调幅度最大，Ki-67的水平最低。同时，它还能维持正常人体细胞的活性，EC100高达1999.7μg/mL。在抗菌活性方面，FCFNC在广谱原核生物和真核生物病原体中提供了70%的生长抑制 。此外，FCFNCs的协同作用以剂量依赖的方式破坏了预先建立的生物膜和藻类生长。然而，作为生物吸附剂，FCFNCs对孔雀石绿和刚果红的脱色率为68%(200g/L)，修复效果显著，FCFNCs吸附的染料的红外光谱和修复后溶液的微毒性/细胞毒性证实了这一点。这项研究为CuFe-杂化纳米复合材料在几个应用领域的招募提供了新的见解。
The quest for eco-friendly and biocompatible nanoparticles (NPs) is an urgent issue in the agenda of the scientific community and applied technology, which compressing synthesis routes. For the first time, a simple route for the biosynthesis of functionalized CuFe-hybrid nanocomposites (FCFNCs) was achieved using Streptomyces cyaneofuscatus through a simultaneous bioreduction strategy of Cu and Fe salts. The suitability of FCFNCs was evaluated medically and environmentally as an anticancer agent, antimicrobial agent and dye bio-sorbent. The physicochemical characteristics of FCFNCs using XRD, EDX, elemental mapping, FTIR, UV–Vis., TEM and ζ-potential confirmed the formation of spheres agglomerated into chains (37 ± 2.2 nm), self-functionalized nanocomposite by proteinaceous moieties with considerable stability (− 26.2 mV). As an anticancer agent, FCFNCs displayed the highest apoptotic impact (> 77.7%) on Caco-2, HepG-2, MCF-7 and PC-3 cancer cells at IC50 ≤ 17.21 μg/mL with the maximum up regulation of p53 and caspase 3 expression and the lowest Ki-67 level, relative to both functionalized CuNPs (FCNPs) and FeNPs (FFNPs). Meanwhile, it maintained the viability of normal human cells by EC100 up to 1999.7 μg/mL. Regarding the antimicrobial activity, FCFNCs offered > 70% growth reduction among wide spectrum prokaryotic and eukaryotic pathogens. Additionally, the synergistic feature of FCFNCs disintegrated the pre-established biofilm and algal growth in a dose-dependent manner. However, as a bio-sorbent, FCFNCs decolorized > 68% of malachite green and congo red dyes (200 mg/L), reflecting considerable remediation efficiency, confirmed by FTIR of FCFNCs- adsorbed dyes and microtoxicity/cytotoxicity of solutions after remediation. This study offers new insights into promising CuFe-hybrid nanocomposites for recruitment in several applications.
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影响因子：
3.1
作者：
Akinsiku AA;Dare EO;Ajanaku KO;Ajani OO;Olugbuyiro JAO;Siyanbola TO;Ejilude O;Emetere ME
通讯作者：
Emetere ME
影响因子：
3
作者：
Bakina, O. V.;Glazkova, E. A.;Lerner, M. I.
通讯作者：
Lerner, M. I.
DOI：
10.1016/j.jphotobiol.2018.05.028
发表时间：
2018-08-01
影响因子：
5.4
作者：
Al-Asfar, Aisha;Zaheer, Zoya;Aazam, Elham Shafik
通讯作者：
Aazam, Elham Shafik
影响因子：
1.7
作者：
Chatzimitakos, Theodoros;Kallimanis, Aristeidis;Stalikas, Constantine D.
通讯作者：
Stalikas, Constantine D.
影响因子：
2.9
作者：
GRIFFITH, OW
通讯作者：
GRIFFITH, OW