Monocyte and Macrophage Dynamics in the Cardiovascular System: JACC Macrophage in CVD Series (Part 3).
Monocyte and Macrophage Dynamics in the Cardiovascular System: JACC Macrophage in CVD Series (Part 3).
复制标题
心血管系统中的单核细胞与巨噬细胞动态：《美国心脏病学会杂志》（JACC）“心血管疾病中的巨噬细胞”系列（第3部分）
DOI：
10.1016/j.jacc.2018.08.2150
复制
发表时间：
2018-10-30
影响因子：
24
通讯作者：
Kovacic JC
中科院分区：
文献类型：
--
作者：
Fayad ZA;Swirski FK;Calcagno C;Robbins CS;Mulder W;Kovacic JC
长期以来，人们认识到骨髓是循环单核细胞的主要来源，这些单核细胞后来可能成为动脉粥样硬化病变中的巨噬细胞。然而，直到最近才开始了解骨髓、单核细胞/巨噬细胞和动脉粥样硬化斑块之间的复杂关系。此外，这些相互作用的全身性质，也涉及额外的隔室，如髓外造血部位（即，脾），只是刚刚变得明显。与此同时，成像和细胞标记技术的进步为动脉粥样硬化病变和全身水平的单核细胞/巨噬细胞运输的体内成像开辟了新的机会。在这一部分3的4部分审查系列涵盖巨噬细胞在心血管疾病中，我们交叉系统生物学与先进的成像技术，探讨单核细胞和巨噬细胞在心血管系统的动力学，重点是如何在系统水平的事件可能会影响局部动脉粥样硬化斑块生物学。巨噬细胞是局部动脉粥样硬化斑块生物学的基础。然而，人们越来越认识到骨髓、单核细胞/巨噬细胞和动脉粥样硬化病变之间的系统性相互作用的重要性。同时，成像技术的进步为在局部和全身水平对单核细胞/巨噬细胞运输进行体内成像开辟了新的机会。在这篇涵盖心血管疾病中巨噬细胞的4部分综述系列的第3部分中，我们将系统生物学与先进的成像技术交叉，以探索心血管系统中的巨噬细胞/单核细胞动力学，重点是系统水平的事件如何影响局部斑块生物学。
It has long been recognized that the bone marrow is the primary site of origin for circulating monocytes that may later become macrophages in atherosclerotic lesions. However, only in recent times has the complex relationship between the bone marrow, monocytes/macrophages and atherosclerotic plaques begun to be understood. Moreover, the systemic nature of these interactions, which also involves additional compartments such as extra-medullary hematopoietic sites (i.e., spleen), are only just becoming apparent. In parallel, progressive advances in imaging and cell labeling techniques have opened new opportunities for in vivo imaging of monocyte/macrophage trafficking in atherosclerotic lesions and at the systemic level. In this part 3 of a 4-part review series covering the macrophage in cardiovascular disease we intersect systemic biology with advanced imaging techniques to explore monocyte and macrophage dynamics in the cardiovascular system, with an emphasis on how events at the systemic level might impact local atherosclerotic plaque biology. Macrophages are fundamental to local atherosclerotic plaque biology. However, there has been a growing appreciation of the importance of the systemic interactions between the bone marrow, monocytes/macrophages and atherosclerotic lesions. In parallel, advances in imaging techniques have opened new opportunities for in vivo imaging of monocyte/macrophage trafficking both at the local and systemic levels. In this part 3 of a 4-part review series covering the macrophage in cardiovascular disease we intersect systemic biology with advanced imaging techniques to explore macrophage/monocyte dynamics in the cardiovascular system, with an emphasis on how events at the systemic level impact local plaque biology.
登录
查看更多内容
影响因子：
14
作者：
Calcagno, Claudia;Lairez, Olivier;Fayad, Zahi A.
通讯作者：
Fayad, Zahi A.
DOI：
10.1007/s00259-013-2518-4
发表时间：
2013-12
影响因子：
9.1
作者：
Calcagno, Claudia;Ramachandran, Sarayu;Izquierdo-Garcia, David;Mani, Venkatesh;Millon, Antoine;Rosenbaum, David;Tawakol, Ahmed;Woodward, Mark;Bucerius, Jan;Moshier, Erin;Godbold, James;Kallend, David;Farkouh, Michael E.;Fuster, Valentin;Rudd, James H. F.;Fayad, Zahi A.
通讯作者：
Fayad, Zahi A.
DOI：
10.1016/j.ejvs.2014.01.017
发表时间：
2014-05-01
影响因子：
5.7
作者：
Chan, J. M. S.;Monaco, C.;Gibbs, R. G. J.
通讯作者：
Gibbs, R. G. J.
影响因子：
64.8
作者：
Busch, Katrin;Klapproth, Kay;Rodewald, Hans-Reimer
通讯作者：
Rodewald, Hans-Reimer
影响因子：
168.9
作者：
Fayad, Zahi A.;Mani, Venkatesh;Woodward, Mark;Kallend, David;Abt, Markus;Burgess, Tracy;Fuster, Valentin;Ballantyne, Christie M.;Stein, Evan A.;Tardif, Jean-Claude;Rudd, James H. F.;Farkouh, Michael E.;Tawakol, Ahmed
通讯作者：
Tawakol, Ahmed