Irisin plays an important role in the outcomes of newly diagnosed prediabetes in adults in Guiyang, China.
Irisin plays an important role in the outcomes of newly diagnosed prediabetes in adults in Guiyang, China.
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鸢尾素对中国贵阳市新诊断的成人糖尿病前期患者的治疗结果发挥着重要作用。
DOI：
10.1111/jdi.13416
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发表时间：
2021-05
影响因子：
3.2
通讯作者：
Shi L
中科院分区：
文献类型：
--
作者：
He X;Zhang Q;Peng N;Hu Y;Li H;Chen Z;Liu R;Xu S;Zhang M;He J;Shi L
探讨鸢尾素在新诊断的前驱糖尿病预后中的潜在作用。数据来自中国糖尿病患者癌症风险评估贵阳分中心：一项纵向（REACTION）研究。共有2530名参与者在基线时新诊断为前驱糖尿病，并完成了随访。巢式1:1病例对照研究包括161名随访时患有糖尿病的参与者，以及161名年龄和性别匹配的对照组。随访研究包括86对匹配的病例对照。采用酶联免疫吸附法测定空腹血清鸢尾素水平。患者血清鸢尾素基线水平高于对照组（P = 0.002）；高基线血清鸢尾素水平是糖尿病发生的独立危险因素（优势比1.235,95%可信区间1.025-1.488）。在调整年龄、性别、体重指数、糖化血红蛋白（HbA1c）、吸烟、运动和糖尿病家族史后，鸢尾素水平最高四分位数的受试者患糖尿病的风险高于最低四分位数的受试者（优势比3.065,95%置信区间1.511-6.218）。随访期间，这些病例的鸢尾素水平下降幅度大于对照组（P < 0.001）。基线血清鸢尾素水平与随访期间鸢尾素下降程度呈正相关（r = 0.773, P < 0.001）。校正混杂因素后，鸢尾素含量下降高于中位数的受试者患糖尿病的风险更高（优势比5.077,95%置信区间2.112-12.206）。鸢尾素可能在贵阳地区新诊断的成人前驱糖尿病的预后中发挥重要作用，并可以预测这些个体发展为糖尿病的风险。这是第一个纵向研究鸢尾素在新诊断的前驱糖尿病预后中的潜在作用，以及它是否可以预测糖尿病前驱个体的糖尿病。我们认为我们的研究对文献做出了重大贡献，因为我们发现血清鸢尾素水平与新诊断的前驱糖尿病的预后之间存在明确的关联。
To explore the potential role of irisin in the outcomes of newly diagnosed prediabetes. Data were obtained from the Guiyang subcenter of the Risk Evaluation of cAncers in Chinese diabeTic Individuals: a lONgitudinal (REACTION) study. A total of 2,530 participants had newly diagnosed prediabetes at baseline and completed follow up. The nested 1:1 case–control study included 161 participants who developed diabetes mellitus at follow up, and 161 age‐ and sex‐matched controls. The follow‐up study included 86 matched case–control pairs. Fasting serum irisin levels were measured using enzyme‐linked immunosorbent assay. Baseline serum irisin levels were higher in the cases than in the controls (P = 0.002); high baseline serum irisin levels were an independent risk factor for the development of diabetes (odds ratio 1.235, 95% confidence interval 1.025–1.488). After adjustment for age, sex, body mass index, glycated hemoglobin (HbA1c), smoking, exercise, and family history of diabetes, subjects in the highest quartile of irisin levels had a higher risk of diabetes than those in the lowest quartile (odds ratio 3.065, 95% confidence interval 1.511–6.218). The extent of decrease in irisin levels during follow‐up was greater in the cases than in the controls (P < 0.001). Baseline serum irisin levels were positively correlated with the extent of decrease in irisin during follow‐up (r = 0.773, P < 0.001). After adjustment for confounding factors, subjects with a decrease of irisin above the median had much higher risk for diabetes (odds ratio 5.077, 95% confidence interval 2.112–12.206). Irisin might play an important role in the outcomes of newly diagnosed prediabetes in adults in Guiyang, and can predict the risk for developing diabetes in these individuals. This is the first longitudinal study to investigate the potential role of irisin in the outcomes of newly diagnosed prediabetes and whether it can be a predictor of diabetes in prediabetic individuals. We believe that our study makes a significant contribution to the literature, because we found a clear association between serum irisin levels and the outcomes of newly diagnosed prediabetes.
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影响因子：
9.3
作者：
Rana KS;Pararasa C;Afzal I;Nagel DA;Hill EJ;Bailey CJ;Griffiths HR;Kyrou I;Randeva HS;Bellary S;Brown JE
通讯作者：
Brown JE
影响因子：
44.5
作者：
Chan, Juliana C. N.;Zhang, Yuying;Ning, Guang
通讯作者：
Ning, Guang
影响因子：
5.8
作者：
Park, Kyung Hee;Zaichenko, Lesya;Mantzoros, Christos S.
通讯作者：
Mantzoros, Christos S.
影响因子：
9.8
作者：
Crujeiras, Ana B.;Angeles Zulet, M.;Casanueva, Felipe F.
通讯作者：
Casanueva, Felipe F.
影响因子：
1.6
作者：
Huh JH;Ahn SV;Choi JH;Koh SB;Chung CH
通讯作者：
Chung CH