Plasma irisin is elevated in type 2 diabetes and is associated with increased E-selectin levels.
Plasma irisin is elevated in type 2 diabetes and is associated with increased E-selectin levels.
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DOI：
10.1186/s12933-017-0627-2
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发表时间：
2017-11-09
影响因子：
9.3
通讯作者：
Brown JE
中科院分区：
文献类型：
--
作者：
Rana KS;Pararasa C;Afzal I;Nagel DA;Hill EJ;Bailey CJ;Griffiths HR;Kyrou I;Randeva HS;Bellary S;Brown JE
鸢尾素是一种主要由运动后骨骼肌释放的激素，可增加脂肪组织的能量消耗。运动后脂肪细胞还可以释放鸢尾素，作为局部脂肪因子诱导白色脂肪组织呈现棕色脂肪组织样表型，这表明鸢尾素及其受体可能代表治疗肥胖和肥胖相关糖尿病的新分子靶点。先前的报告提供了关于 2 型糖尿病 (T2DM) 患者循环鸢尾素水平的相互矛盾的证据。本研究调查了 79 名 T2DM 个体的血浆鸢尾素浓度，评估了其与节段身体成分、内皮功能障碍标志物和外周血单核细胞端粒长度 (TL) 测量值的潜在关联。与我们之前在健康志愿者中报告的水平相比，这组 T2DM 患者静息、禁食过夜的血浆鸢尾素水平显着较高（p < 0.001）。此外，血浆鸢尾素与体重指数 (p = 0.04)、体脂百分比 (p = 0.03)、HbA1c (p = 0.03) 和可溶性 E-选择素 (p < 0.001) 呈正相关。在 T2DM 患者中观察到血浆鸢尾素与内脏肥胖之间存在显着负相关 (p = 0.006)。多元回归分析表明，循环可溶性 E-选择素水平可以通过血浆鸢尾素来预测 (p = 0.004)。此外，培养的人脐静脉内皮细胞 (HUVEC) 暴露于 200 ng/ml 鸢尾素 4 小时后，E-选择素显着增加四倍，ICAM-1 基因表达增加 2.5 倍（分别为 p = 0.001 和 p = 0.015），条件培养基中可溶性 E-选择素增加 1.8 倍（p < 0.05）。这些数据表明，T2DM 患者血浆鸢尾素升高与肥胖指数相关，并且鸢尾素可能参与伴随肥胖和 T2DM 的促动脉粥样硬化内皮紊乱。因此，鸢尾素可能在肥胖和心血管糖尿病领域构成潜在的新治疗机会。
Irisin is a hormone released mainly from skeletal muscle after exercise which increases adipose tissue energy expenditure. Adipocytes can also release irisin after exercise, acting as a local adipokine to induce white adipose tissue to take on a brown adipose tissue-like phenotype, suggesting that irisin and its receptor may represent a novel molecular target for the treatment of obesity and obesity-related diabetes. Previous reports provide conflicting evidence regarding circulating irisin levels in patients with type 2 diabetes (T2DM). This study investigated plasma irisin concentrations in 79 T2DM individuals, assessing potential associations with measures of segmental body composition, markers of endothelial dysfunction and peripheral blood mononuclear cell telomere length (TL). Resting, overnight-fasted plasma irisin levels were significantly higher in this group of T2DM patients compared with levels we previously reported in healthy volunteers (p < 0.001). Moreover, plasma irisin displayed a positive correlation with body mass index (p = 0.04), body fat percentage (p = 0.03), HbA1c (p = 0.03) and soluble E-selectin (p < 0.001). A significant negative association was observed between plasma irisin and visceral adiposity (p = 0.006) in T2DM patients. Multiple regression analysis revealed that circulating soluble E-selectin levels could be predicted by plasma irisin (p = 0.004). Additionally, cultured human umbilical vein endothelial cells (HUVEC) exposed to 200 ng/ml irisin for 4 h showed a significant fourfold increase in E-selectin and 2.5-fold increase in ICAM-1 gene expression (p = 0.001 and p = 0.015 respectively), and there was a 1.8-fold increase in soluble E-selectin in conditioned media (p < 0.05). These data suggest that elevated plasma irisin in T2DM is associated with indices of adiposity, and that irisin may be involved in pro-atherogenic endothelial disturbances that accompany obesity and T2DM. Accordingly, irisin may constitute a potentially novel therapeutic opportunity in the field of obesity and cardiovascular diabetology.
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影响因子：
--
作者：
Elizondo-Montemayor L;Silva-Platas C;Torres-Quintanilla A;Rodríguez-López C;Ruiz-Esparza GU;Reyes-Mendoza E;Garcia-Rivas G
通讯作者：
Garcia-Rivas G
影响因子：
2.5
作者：
Hew-Butler T;Landis-Piwowar K;Byrd G;Seimer M;Seigneurie N;Byrd B;Muzik O
通讯作者：
Muzik O
影响因子：
5.1
作者：
Choi, Yeon-Kyung;Kim, Mi-Kyung;Park, Keun-Gyu
通讯作者：
Park, Keun-Gyu
影响因子：
3.2
作者：
de la Iglesia, Rocio;Lopez-Legarrea, Patricia;Martinez, Jose A.
通讯作者：
Martinez, Jose A.
影响因子：
--
作者：
Lee, Hye Jeong;Lee, Jung Ok;Kim, Hyeon Soo
通讯作者：
Kim, Hyeon Soo