Association of adherence to lifestyle recommendations and risk of colorectal cancer: a prospective Danish cohort study.
Association of adherence to lifestyle recommendations and risk of colorectal cancer: a prospective Danish cohort study.
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DOI：
10.1136/bmj.c5504
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发表时间：
2010-10-26
期刊：
影响因子：
--
通讯作者：
Tjønneland A
中科院分区：
文献类型：
--
作者：
Kirkegaard H;Johnsen NF;Christensen J;Frederiksen K;Overvad K;Tjønneland A
目的评价基于五种生活方式因素建议的简单生活方式指数与结直肠癌发病率之间的关系，并估计因未遵守建议而导致结直肠癌病例的比例。设计前瞻性队列研究。丹麦哥本哈根和奥胡斯的总人口。参与者55487名男性和女性，1993- 1997年基线年龄为50-64岁，以前未被诊断患有癌症。主要结局指标结直肠癌风险与生活方式指数得分（基于体力活动、腰围、吸烟、饮酒和饮食（膳食纤维、脂肪能量百分比、红肉和加工肉、水果和蔬菜））相关，通过Cox回归建模。结果在平均9.9年的随访期间，678名男性和女性被诊断出结直肠癌。在对潜在的混杂因素进行调整后，生活方式指数每增加一分，对应于满足了一项额外的建议，结直肠癌的风险就会降低（发病率比0.89(95%可信区间0.82至0.96)）。在这一人群中，估计总共有13% （95% CI为4%至22%）的结直肠癌病例可归因于除了最健康的参与者外，所有参与者中仅缺乏对一项额外建议的遵守。如果所有参与者都遵循了这五项建议，23%（9%至37%）的结直肠癌病例本可以避免。结肠癌和直肠癌的结果相似，但只有结肠癌有统计学意义。结论：坚持体育锻炼、腰围、吸烟、饮酒和饮食方面的建议可以显著降低结直肠癌的风险，在这一人群中，23%的病例可能归因于缺乏对五种生活方式建议的遵守。生活方式指数结构简单，便于在公共卫生实践中使用。
Objectives To evaluate the association between a simple lifestyle index based on the recommendations for five lifestyle factors and the incidence of colorectal cancer, and to estimate the proportion of colorectal cancer cases attributable to lack of adherence to the recommendations. Design Prospective cohort study. Setting General population of Copenhagen and Aarhus, Denmark. Participants 55 487 men and women aged 50-64 years at baseline (1993-7), not previously diagnosed with cancer. Main outcome measure Risk of colorectal cancer in relation to points achieved in the lifestyle index (based on physical activity, waist circumference, smoking, alcohol intake, and diet (dietary fibre, energy percentage from fat, red and processed meat, and fruits and vegetables)) modelled through Cox regression. Results During a median follow-up of 9.9 years, 678 men and women had colorectal cancer diagnosed. After adjustment for potential confounders, each additional point achieved on the lifestyle index, corresponding to one additional recommendation that was met, was associated with a lower risk of colorectal cancer (incidence rate ratio 0.89 (95% confidence interval 0.82 to 0.96). In this population an estimated total of 13% (95% CI 4% to 22%) of the colorectal cancer cases were attributable to lack of adherence to merely one additional recommendation among all participants except the healthiest. If all participants had followed the five recommendations 23% (9% to 37%) of the colorectal cancer cases might have been prevented. Results were similar for colon and rectal cancer, but only statistically significant for colon cancer. Conclusions Adherence to the recommendations for physical activity, waist circumference, smoking, alcohol intake, and diet may reduce colorectal cancer risk considerably, and in this population 23% of the cases might be attributable to lack of adherence to the five lifestyle recommendations. The simple structure of the lifestyle index facilitates its use in public health practice.
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影响因子：
7.1
作者：
Larsson, Susanna C.;Wolk, Alicja
通讯作者：
Wolk, Alicja
影响因子：
5
作者：
Haveman-Nies, A;de Groot, LPGM;van Staveren, WA
通讯作者：
van Staveren, WA
影响因子：
6.4
作者：
Moskal, Aurelie;Norat, Teresa;Riboli, Elio
通讯作者：
Riboli, Elio
在一项大型队列研究中，健康的健康生活方式评分和胰腺癌的风险。
影响因子：
--
作者：
Jiao, Li;Mitrou, Panagiota N.;Reedy, Jill;Graubard, Barry I.;Hollenbeck, Albert R.;Schatzkin, Arthur;Stolzenberg-Solomon, Rachael
通讯作者：
Stolzenberg-Solomon, Rachael
影响因子：
39.2
作者：
Cho, EY;Smith-Warner, SA;Hunter, DJ
通讯作者：
Hunter, DJ