A combined healthy lifestyle score and risk of pancreatic cancer in a large cohort study.
A combined healthy lifestyle score and risk of pancreatic cancer in a large cohort study.
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在一项大型队列研究中，健康的健康生活方式评分和胰腺癌的风险。
DOI：
10.1001/archinternmed.2009.46
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发表时间：
2009-04-27
影响因子：
--
通讯作者：
Stolzenberg-Solomon, Rachael
中科院分区：
文献类型：
--
作者：
Jiao, Li;Mitrou, Panagiota N.;Reedy, Jill;Graubard, Barry I.;Hollenbeck, Albert R.;Schatzkin, Arthur;Stolzenberg-Solomon, Rachael
吸烟、饮酒、饮食、身体质量指数(BMI)和体力活动与胰腺癌的关系已经被独立研究。我们生成了一个健康的生活方式评分，以调查它们对胰腺癌风险的联合影响。在美国国立卫生研究院-美国退休人员协会未来的饮食和健康研究中，共有450,416名年龄在50-71岁的参与者完成了基线食物频率问卷(1995-1996年)，得出了饮食和生活方式的信息，并进行了跟踪调查，直至2003年12月。我们确定了1057例符合条件的偶发胰腺癌病例。根据目前的流行病学证据，参与者在五个可改变的生活方式因素上进行了评分，即“不健康”(0分)或“健康”(1分)。参与者在每个生活方式因素上得到1分：不吸烟、限制饮酒、坚持地中海饮食模式、18≤体重指数和25公斤/平方米，或定期体力活动。综合得分(0-5分)由五个因素的得分相加而得。用COX比例风险回归模型估计胰腺癌的相对危险度(RR)和95%可信区间(CI)。与最低的综合得分(0分)相比，得分最高(5分)的所有参与者患胰腺癌的风险降低58%(RR，0.42；95%CI，0.26-0.66，P趋势与0.001)。得分不到5分可以解释我们人口中27%的胰腺癌病例。这项大型研究表明，在一个综合了五个可改变的生活方式因素的指数上，得分高而不是低，大大降低了一个人患胰腺癌的风险。
Smoking, alcohol use, diet, body mass index (BMI), and physical activity have been studied independently in relation to pancreatic cancer. We generated a healthy lifestyle score to investigate their joint effect on pancreatic cancer risk. In the prospective National Institutes of Health-AARP Diet and Health Study, a total of 450,416 participants aged 50–71 years completed the baseline food frequency questionnaire (1995–1996) eliciting diet and lifestyle information and were followed up through December 2003. We identified 1,057 eligible incident pancreatic cancer cases. Participants were scored for five modifiable lifestyle factors as “unhealthy” (0 points) or “healthy” (1 point) based on current epidemiologic evidence. Participants received 1 point for each respective lifestyle factor: nonsmoking, limited alcohol use, adherence to the Mediterranean dietary pattern, 18 ≤ BMI <25 kg/m2, or regular physical activity. A combined score (0–5 points) was calculated by summing the scores from the five factors. Cox proportional hazards regression models were used to estimate relative risks (RRs) and 95% confidence intervals (CIs) for pancreatic cancer. Compared to the lowest combined score (0 points), the highest score (5 points) was associated with a 58% reduction in risk of developing pancreatic cancer in all participants (RR, 0.42; 95% CI, 0.26–0.66, P trend < .001). Scores of less than 5 points explained 27% of pancreatic cancer cases in our population. This large study suggests that having a high, as opposed to a low, score on an index combining five modifiable lifestyle factors substantially reduces one’s risk of pancreatic cancer.
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影响因子：
10.4
作者：
HECHT, SS;CARMELLA, SG;PETERSON, LA
通讯作者：
PETERSON, LA
影响因子：
8.8
作者：
通讯作者：
--
影响因子：
4.2
作者：
Dixon, L. Beth;Subar, Amy F.;Hayes, Richard B.
通讯作者：
Hayes, Richard B.
影响因子：
158.5
作者：
Trichopoulou, A;Costacou, T;Trichopoulos, D
通讯作者：
Trichopoulos, D
影响因子：
5
作者：
Schatzkin, A;Subar, AF;Kipnis, V
通讯作者：
Kipnis, V