B-Cell Immunophenotyping to Predict Vaccination Outcome in the Immunocompromised - A Systematic Review.
B-Cell Immunophenotyping to Predict Vaccination Outcome in the Immunocompromised - A Systematic Review.
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DOI：
10.3389/fimmu.2021.690328
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发表时间：
2021
影响因子：
7.3
通讯作者：
Berkowska MA
中科院分区：
文献类型：
--
作者：
Diks AM;Overduin LA;van Leenen LD;Slobbe L;Jolink H;Visser LG;van Dongen JJM;Berkowska MA
接种疫苗是预防普通人群感染的最有效措施。它的效率很大程度上取决于免疫系统的功能和组成。如果免疫系统缺乏关键组成部分，即使有完整的疫苗接种计划，患者也不会得到充分保护。抗原特异性血清免疫球蛋白水平是广泛使用的保护性相关指标。这些是终末分化的B细胞--浆细胞的产物。在这里，我们回顾了有关B细胞组成和功能异常如何影响疫苗免疫反应的文献。在对五个主要文献数据库的搜索中，发现了2000年及以后发表的6537篇独特的文章。75篇文章沿着三条主要研究路线进行：生命的四肢、免疫缺陷和免疫抑制。议定书的详细内容载于《国际预期系统评价登记册》[PROSPERO(登记号：CRD42021226683)]。大多数文章调查了成年人的免疫反应，其中肺炎球菌和流感疫苗的接种占了很大比例。缺乏基线信息是被排除在外的最常见原因。与研究组无关，基线测量的三个参数在评估疫苗效力方面似乎具有预测价值：(1)B细胞亚群的分布(主要是记忆B细胞的减少)，(2)是否存在耗尽/激活的B细胞，或表型异常的B细胞，以及(3)先前存在的免疫记忆。在这篇综述中，我们展示了如何利用免疫前(基线)的循环B细胞知识来预测疫苗的效果。我们希望这一概述将有助于优化疫苗接种策略，特别是在免疫功能低下的患者中。
Vaccination is the most effective measure to prevent infections in the general population. Its efficiency strongly depends on the function and composition of the immune system. If the immune system lacks critical components, patients will not be fully protected despite a completed vaccination schedule. Antigen-specific serum immunoglobulin levels are broadly used correlates of protection. These are the products of terminally differentiated B cells – plasma cells. Here we reviewed the literature on how aberrancies in B-cell composition and function influence immune responses to vaccinations. In a search through five major literature databases, 6,537 unique articles published from 2000 and onwards were identified. 75 articles were included along three major research lines: extremities of life, immunodeficiency and immunosuppression. Details of the protocol can be found in the International Prospective Register of Systematic Reviews [PROSPERO (registration number CRD42021226683)]. The majority of articles investigated immune responses in adults, in which vaccinations against pneumococci and influenza were strongly represented. Lack of baseline information was the most common reason of exclusion. Irrespective of study group, three parameters measured at baseline seemed to have a predictive value in assessing vaccine efficacy: (1) distribution of B-cell subsets (mostly a reduction in memory B cells), (2) presence of exhausted/activated B cells, or B cells with an aberrant phenotype, and (3) pre-existing immunological memory. In this review we showed how pre-immunization (baseline) knowledge of circulating B cells can be used to predict vaccination efficacy. We hope that this overview will contribute to optimizing vaccination strategies, especially in immunocompromised patients.
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影响因子：
6.4
作者：
Chang, Q;Abadi, J;Pirofski, L
通讯作者：
Pirofski, L
影响因子：
5.5
作者：
Chu, Christina S.;Boyer, Jean D.;Sullivan, Kathleen E.
通讯作者：
Sullivan, Kathleen E.
影响因子：
15.9
作者：
Antunes, Ricardo da Silva;Babor, Mariana;Sette, Alessandro
通讯作者：
Sette, Alessandro
影响因子：
8.8
作者：
Bennett, Nancy M.;Whitney, Cynthia G.;Dooling, Kathleen L.
通讯作者：
Dooling, Kathleen L.
影响因子：
5.5
作者：
Cagigi, Alberto;Pensieroso, Simone;Chiodi, Francesca
通讯作者：
Chiodi, Francesca