Processive ubiquitin chain formation by the anaphase-promoting complex.

Processive ubiquitin chain formation by the anaphase-promoting complex.
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DOI:
10.1016/j.semcdb.2011.03.009
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发表时间:
2011-08
影响因子:
7.3
通讯作者:
Rape, Michael
Rape, Michael
中科院分区:
生物学2区
文献类型:
--
作者:
Meyer, Hermann-Josef;Rape, Michael

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有丝分裂的进展需要细胞周期调节因子被后期促进复合体泛素化,导致它们的蛋白酶体降解。虽然APC/C在有丝分裂过程中有几种机制参与调节,但APC/C能够通过利用泛素链组装过程中的差异来区分其许多底物。在这里,我们讨论APC/C如何实现过程中泛素链的形成,以触发有丝分裂过程中细胞周期调节因子的顺序降解。
Progression through mitosis requires the sequential ubiquitination of cell cycle regulators by the anaphase-promoting complex, resulting in their proteasomal degradation. Although several mechanisms contribute to APC/C regulation during mitosis, the APC/C is able to discriminate between its many substrates by exploiting differences in the processivity of ubiquitin chain assembly. Here, we discuss how the APC/C achieves processive ubiquitin chain formation to trigger the sequential degradation of cell cycle regulators during mitosis.
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