Diffusion tensor imaging of articular cartilage using a navigated radial imaging spin-echo diffusion (RAISED) sequence.
Diffusion tensor imaging of articular cartilage using a navigated radial imaging spin-echo diffusion (RAISED) sequence.
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DOI：
10.1007/s00330-018-5780-9
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发表时间：
2019-05
影响因子：
5.9
通讯作者：
Raya JG
中科院分区：
文献类型：
--
作者：
Duarte A;Ruiz A;Ferizi U;Bencardino J;Abramson SB;Samuels J;Krasnokutsky-Samuels S;Raya JG
为了验证用于3T关节软骨高分辨率扩散张量成像(DTI)的径向成像自旋回波扩散张量(RAISED)序列的有效性，描述了RAIDED序列的实现，包括所使用的非线性运动校正算法。在体模上测试了其对涡流的稳健性，并通过自由水随温度变化的扩散测量来评估测量的准确性。通过与单次激发扩散加权回波平面成像(EPI)测量的比较，验证了运动校正的有效性。无症状者(n=6)、可疑(Kellgren-Lawrence[KL]1级，n=9)和轻度(KL=2，n=9)症状性膝骨性关节炎(OA)患者获得DTI。计算未校正和校正后的MD和FA值。对3名无症状受试者和3名OA受试者进行了DTI获得的重测评估。全球重测重复性的均方根变异系数MD为3.54%，FA为5.34%。KL1组双侧股骨髁MD显著增加(7~9%)，KL2组内侧(11~17%)和外侧(10~12%)MD显著增加。随着KL分级的增加，平均FA值呈下降趋势，KL 1的股骨内侧髁(−11%)和KL 2的所有三个间隔区(−18~−11%)的FA值均较低。两组间的MD和FA只有在运动矫正后才有显著差异。提出的重建框架的提升序列提供了在3T时体内DTI参数的可重复性评估，并可能在大范围感兴趣的区域中提供疾病的早期阶段。
To validate a radial imaging spin-echo diffusion tensor (RAISED) sequence for high-resolution diffusion tensor imaging (DTI) of articular cartilage at 3 T. The RAISED sequence implementation is described, including the used non-linear motion correction algorithm. The robustness to eddy currents was tested on phantoms, and accuracy of measurement was assessed with measurements of temperature-dependent diffusion of free water. Motion correction was validated by comparing RAISED with single-shot diffusion-weighted echo-planar imaging (EPI) measures. DTI was acquired in asymptomatic subjects (n=6) and subjects with doubtful (Kellgren-Lawrence [KL] grade 1, n=9) and mild (KL=2, n=9) symptomatic knee osteoarthritis (OA). MD and FA values without correction, and after all corrections were calculated. A test-retest evaluation of the DTI acquisition on 3 asymptomatic and 3 OA subjects was also performed. The root-mean-squared coefficient of variation of the global test-retest reproducibility was 3.54% for MD and 5.34% for FA. MD was significantly increased in both femoral condyles (7–9%) of KL 1 and in the medial (11–17%) and lateral (10–12%) compartments of KL 2 subjects. Averaged FA presented a trend of lower values with increasing KL grade, which was significant for the medial femoral condyle (−11%) of KL 1 and all three compartments in KL 2 subjects (−18–−11%). Group differences in MD and FA were only significant after motion correction. The RAISED sequence with the proposed reconstruction framework provides reproducible assessment of DTI parameters in vivo at 3 T, and potentially the early stages of the disease in large regions of interest.
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影响因子：
2.5
作者：
Azuma, Takashi;Nakai, Ryusuke;Tsutsumi, Sadami
通讯作者：
Tsutsumi, Sadami
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作者：
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通讯作者：
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影响因子：
3.3
作者：
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通讯作者：
Pauly, JM
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3.3
作者：
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通讯作者：
Scheffler, Klaus
影响因子：
3.3
作者：
Madelin, Guillaume;Babb, James S.;Regatte, Ravinder R.
通讯作者：
Regatte, Ravinder R.