The appearance of Tregs in cancer nest is a promising independent risk factor in colon cancer
The appearance of Tregs in cancer nest is a promising independent risk factor in colon cancer
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癌巢中Tregs的出现是结肠癌有希望的独立危险因素
DOI：
10.1007/s00432-013-1500-7
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发表时间：
2013-09
影响因子：
3.6
通讯作者：
Zheng, Jun-Nian
中科院分区：
文献类型：
--
作者：
Zhang, Bao-Fu;Li, Hui-Zhong;Bai, Jin;Zheng, Jun-Nian
目的探讨肿瘤浸润性调节性T细胞（tumor-infiltrating regulatory T cells，TCFs）在结肠癌患者术后癌巢、癌间质、正常黏膜及FOXP 3阳性癌细胞分布中的预测价值。采用组织芯片和免疫组化染色技术检测肿瘤组织中TGFAP的分布情况，以中位数为界值进行Kaplan-Meier和考克斯回归分析，评价TGFAP对患者预后的影响癌巢中的T淋巴细胞计数明显低于相应癌间质组织（P< 0.001）肿瘤内Tlymphocyte计数增高与预后良好相关（P <0. 05），癌巢内Tlymphocyte计数增高与预后不良相关（P<0. 05），是影响总生存率的独立预后因素（P<0. 05）。FOXP 3阳性癌细胞的出现与预后有关（P< 0.05）。另外，FOXP 3阳性癌细胞在有淋巴结浸润的结肠癌患者中的出现率较高（P< 0.001），而在TNM分期较早的结肠癌患者中的出现率较低（P< 0.01）。肿瘤细胞在癌巢和癌间质中发挥不同的作用。结论：结肠癌组织中TGFAP的表达是影响结肠癌患者生存率的独立危险因素。FOXP 3阳性癌细胞也可能是结肠癌总生存率的危险因素。
PurposeTo investigate the prognostic value of tumor-infiltrating regulatory T cells (Tregs) in the distribution of cancer nest, cancer stroma and normal mucosa and FOXP3-positive cancer cells in colon cancer patients after resection.MethodsParaffin blocks of operation resection of primary adenocarcinoma of colon were obtained from ninety patients. The distribution of tumor-infiltrating Tregs was detected by tissue microarray and immunohistochemistry staining technique to evaluate the prognostic effects by Kaplan–Meier and Cox regression analysis using median values as cutoff.ResultsThe intratumoral Tregs counts were significantly higher than that in corresponding normal mucosa tissues (P< 0.001); the Tregs counts in cancer nest were significantly lower than that in corresponding cancer stroma tissues (P< 0.001); the increased intratumoral Tregs counts were associated with favorable prognosis (P< 0.05); the presence of Tregs in cancer nest was associated with unfavorable prognosis and was an independent prognostic factor for overall survival (P< 0.05). The appearance of FOXP3-positive cancer cells was associated with worse prognosis (P< 0.05). In addition, the frequency of the presence of FOXP3-positive cancer cells was higher in patients with lymphatic invasion (P< 0.001) and lower in patients with early TNM stage (P< 0.01).ConclusionsThe higher tumor-infiltrating Tregs counts are closely associated with the improved prognostic effects of colon carcinoma. Tregs play different roles in cancer nest and cancer stroma. And the appearance of Tregs in cancer nest is a promising independent risk factor for overall survival in colon carcinoma. FOXP3-positive cancer cells may also be a risk factor for overall survival in colon carcinoma.
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影响因子：
3.8
作者：
Ladoire, Sylvain;Arnould, Laurent;Ghiringhelli, Francois
通讯作者：
Ghiringhelli, Francois
体细胞单次攻击可使前列腺中的 X 连锁肿瘤抑制因子 FOXP3 失活。
影响因子：
50.3
作者：
Wang, Lizhong;Liu, Runhua;Li, Weiquan;Chen, Chong;Katoh, Hiroto;Chen, Guo-Yun;McNally, Beth;Lin, Lin;Zhou, Penghui;Zuo, Tao;Cooney, Kathleen A.;Liu, Yang;Zheng, Pan
通讯作者：
Zheng, Pan
影响因子：
50.3
作者：
Bromberg J;Wang TC
通讯作者：
Wang TC
影响因子：
5.3
作者：
Tao, Hiroyuki;Mimura, Yusuke;Ueoka, Hiroshi
通讯作者：
Ueoka, Hiroshi
影响因子：
64.5
作者：
T. Zuo;Lizhong Wang;C. Morrison;Xing Chang;Huiming Zhang;Yan Liu;Yin Wang;Xingluo Liu;M. Ch
通讯作者：
T. Zuo;Lizhong Wang;C. Morrison;Xing Chang;Huiming Zhang;Yan Liu;Yin Wang;Xingluo Liu;M. Ch