A detailed experimental and Monte Carlo analysis of gold nanoparticle dose enhancement using 6 MV and 18 MV external beam energies in a macroscopic scale.

A detailed experimental and Monte Carlo analysis of gold nanoparticle dose enhancement using 6 MV and 18 MV external beam energies in a macroscopic scale.
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DOI:
10.1016/j.apradiso.2021.109638
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发表时间:
2021-05
期刊:
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine
影响因子:
--
通讯作者:
Mayer KM
Mayer KM
中科院分区:
其他
文献类型:
--
作者:
Gray T;Bassiri N;David S;Patel DY;Stathakis S;Kirby N;Mayer KM

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金纳米粒子(GNPs)的剂量增强已经通过实验和蒙特卡罗模拟对6 mV和18 mV的外束放射治疗能量进行了量化。在所测试的最高GNP浓度下,18 mV束流的增强效果最好,DEF为1.02。在大电压能量范围内,DEF随金浓度的增加和能量的增加而增大。在所有数据集中,测量的DEF与模拟的DEF的最大差异为0.3%,显示出良好的一致性。
Dose enhancement due to gold nanoparticles (GNPs) has been quantified experimentally and through Monte Carlo simulations for external beam radiation therapy energies of 6 and 18 MV. The highest enhancement was observed for the 18 MV beam at the highest GNP concentration tested, amounting to a DEF of 1.02. DEF is shown to increase with increasing concentration of gold and increasing energy in the megavoltage energy range. The largest difference in measured vs. simulated DEF across all data sets was 0.3%, showing good agreement.
浓度,纳米颗粒大小,束能和材料对放射治疗剂量增强的影响。
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