Effect of endometrial thickness changes on clinical pregnancy rates after progesterone administration in a single frozen-thawed euploid blastocyst transfer cycle using natural cycles with luteal support for PGT-SR- and PGT-M-assisted reproduction: a retrospective cohort study.
Effect of endometrial thickness changes on clinical pregnancy rates after progesterone administration in a single frozen-thawed euploid blastocyst transfer cycle using natural cycles with luteal support for PGT-SR- and PGT-M-assisted reproduction: a retrospective cohort study.
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子宫内膜厚度变化对孕酮给药后临床妊娠率的影响在单个冷冻融化的胚胎胚泡转移周期中使用天然循环，并支持PGT-SR-和PGT-M辅助繁殖：一项追溯研究。
DOI：
10.1186/s12958-021-00841-x
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发表时间：
2021-10-09
期刊：
影响因子：
--
通讯作者：
Zhang Y
中科院分区：
文献类型：
--
作者：
Jin Z;Li J;Yang E;Shi H;Bu Z;Niu W;Wang F;Huo M;Song H;Zhang Y
目的探讨单次整倍体囊胚移植周期中，孕酮给药日至囊胚移植日子宫内膜厚度变化率是否与妊娠结局相关。所有患者均采用黄体支持的自然周期进行子宫内膜准备，并在植入前基因检测活检后选择单个整倍体囊胚进行移植。在黄体酮给药当日及移植当日经阴道超声测量子宫内膜厚度，测量子宫内膜厚度变化，计算子宫内膜厚度变化率。根据子宫内膜厚度变化率将患者分为三组：子宫内膜厚度压实组、子宫内膜厚度不变组和子宫内膜厚度扩张组。其中，子宫内膜厚度未改变组和扩张组合并为子宫内膜厚度未压实组。对219例整倍体囊胚冻融移植周期子宫内膜超声图像进行了评价。临床妊娠率随子宫内膜厚度变化率的增加而增加，流产率和活产率组间具有可比性。多元logistic回归结果显示，在完全校正模型中，子宫内膜厚度变化比（每10%）越高，临床妊娠率越高（校正优势比[aOR] 1.29； 95%可信区间[CI]， 1.01-1.64; P = 0.040）。同样，根据子宫内膜厚度变化率将患者分为三组，在调整所有协变量后，子宫内膜厚度未压实组对临床妊娠率的影响显著高于子宫内膜厚度压实组。在黄体支持下自然周期制备子宫内膜的整倍体囊胚冻融移植周期中，未使用孕酮压实子宫内膜的周期临床妊娠率较高。在线版本包含补充材料，可在10.1186/s12958-021-00841-x获得。
To investigate whether the endometrial thickness change ratio from the progesterone administration day to the blastocyst transfer day is associated with pregnancy outcomes in a single frozen-thawed euploid blastocyst transfer cycle. All patients used natural cycles with luteal support for endometrial preparation and selected a single euploid blastocyst for transfer after a biopsy for preimplantation genetic testing. The endometrial thickness was measured by transvaginal ultrasound on the progesterone administration day and the transfer day, the change in endometrial thickness was measured, and the endometrial thickness change ratio was calculated. According to the change rate of endometrial thickness, the patients were divided into three groups: the endometrial thickness compaction group, endometrial thickness non-change group and endometrial thickness expansion group. Among them, the endometrial thickness non-change and expansion groups were combined into the endometrial thickness noncompaction group. Ultrasound images of the endometrium in 219 frozen-thawed euploid blastocyst transfer cycles were evaluated. The clinical pregnancy rate increased with the increase in endometrial thickness change ratio, while the miscarriage rate and live birth rate were comparable among the groups. The multiple logistic regression results showed that in the fully adjusted model a higher endometrial thickness change ratio (per 10%) was associated with a higher clinical pregnancy rate (adjusted odds ratio [aOR] 1.29; 95% confidence interval [CI], 1.01–1.64; P = .040). Similarly, when the patients were divided into three groups according to the change rate of endometrial thickness, the endometrial thickness noncompaction group had a significant positive effect on the clinical pregnancy rate compared with the endometrial thickness compaction group after adjusting for all covariates. In frozen-thawed euploid blastocyst transfer cycles in which the endometrium was prepared by natural cycles with luteal support, the clinical pregnancy rate was higher in cycles without endometrial compaction after progesterone administration. The online version contains supplementary material available at 10.1186/s12958-021-00841-x.
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DOI：
10.1093/humrep/dey281
发表时间：
2018-10-01
期刊：
Human reproduction (Oxford, England)
影响因子：
--
作者：
Liu KE;Hartman M;Hartman A;Luo ZC;Mahutte N
通讯作者：
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影响因子：
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影响因子：
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影响因子：
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Riestenberg, Carrie;Quinn, Molly;Kroener, Lindsay
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影响因子：
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