Effect of Endometrial Thickness Change in Response to Progesterone Administration on Pregnancy Outcomes in Frozen-Thawed Embryo Transfer: Analysis of 4465 Cycles.
Effect of Endometrial Thickness Change in Response to Progesterone Administration on Pregnancy Outcomes in Frozen-Thawed Embryo Transfer: Analysis of 4465 Cycles.
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孕酮给药引起的子宫内膜厚度变化对冻融胚胎移植妊娠结局的影响：4465 个周期的分析
DOI：
10.3389/fendo.2020.546232
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发表时间：
2020
影响因子：
5.2
通讯作者：
Kuang Y
中科院分区：
文献类型：
--
作者：
Ye J;Zhang J;Gao H;Zhu Y;Wang Y;Cai R;Kuang Y
目的探讨冻融胚胎移植（FET）周期中子宫内膜厚度（EMT）随孕酮变化对妊娠结局的影响。设计回顾性观察性研究。设置三级保健学术医疗中心。2010年1月至2015年12月期间，4465名不孕妇女在本中心接受了第一次FET治疗。方法：本观察性研究纳入2010年1月至2015年12月4465例首次FET周期患者。分别于给药前1天和FET当天经阴道超声测量EMT，观察EMT变化。主要观察指标：临床妊娠率（CPR）和活产率（LBR）。结果无论采用人工周期、雌激素-孕激素替代疗法（EP）或自然周期（NC）等子宫内膜制备方案，与黄体酮给药前1天相比，FET当天的EMT均可升高、降低或保持稳定。EMT升高、降低和稳定组EP周期CPR分别为48.4%、51.3%和50.7%，而NC周期心肺复苏率分别为49.2%、52.0%和48.9%，两周期三组间差异无统计学意义（P= 0.48， P= 0.49）。EP周期的LBR分别为40.9%、45.9%和42.6%，而NC周期的LBR分别为44.2%、44.8%和42.1%，两组间差异均无统计学意义（P= 0.16， P= 0.66）。此外，心肺复苏术和LBR与EMT增加无显著相关。结论与使用黄体酮前1天相比，FET当天的EMT可能增加、减少或保持稳定。无论给药后EMT发生什么变化，对FET周期的CPR和LBR没有显著影响。
Objective To evaluate whether endometrial thickness (EMT) change in response to progesterone has an effect on pregnancy outcomes in frozen-thawed embryo transfer (FET) cycles. Design Retrospective observational study. Setting Tertiary-care academic medical center. Participants 4465 infertile women undergoing their first FET between January 2010 and December 2015 in our center. Methods This observational study included 4465 patients undergoing their first FET cycles between January 2010 and December 2015. EMT was measured by transvaginal ultrasound one day before progesterone administration and on the day of FET to observe EMT change. Main outcome measures Clinical pregnancy rate (CPR) and the live birthrate (LBR) was discussed. Results Regardless of the endometrial preparation protocols such as artificial cycle, estrogen-progesterone replacement therapy (EP) or natural cycle (NC), EMT may increase, decrease or remain stable on the day of FET compared with that of one day before progesterone administration. CPR in EMT increase, decrease and stable groups were 48.4%, 51.3% and 50.7% in EP cycle versus 49.2%, 52.0% and 48.9% in NC cycle, showing no significant difference between the three groups in both cycles (P= 0.48, P= 0.49). LBR was 40.9%, 45.9% and 42.6% in EP cycle versus 44.2%, 44.8% and 42.1% in NC cycle, also showing no significant difference between the three groups in both cycles (P= 0.16, P= 0.66). In addition, CPR and LBR were not significantly associated with EMT increase. Concludes EMT may increase, decrease or remain stable on the day of FET as compared with that of one day before progesterone administration. Whatever change in EMT that occurs after progesterone administration has no significant effect on CPR and LBR in FET cycles.
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DOI：
10.1093/humrep/dey281
发表时间：
2018-10-01
期刊：
Human reproduction (Oxford, England)
影响因子：
--
作者：
Liu KE;Hartman M;Hartman A;Luo ZC;Mahutte N
通讯作者：
Mahutte N
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DOI：
10.1016/j.ejogrb.2016.05.016
发表时间：
2016-08-01
影响因子：
2.6
作者：
Zhang, Tianjie;He, Yaqiong;Sun, Yun
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Sun, Yun
影响因子：
4
作者：
Oron, Galia;Hiersch, Liran;Ben-Haroush, Avi
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Ben-Haroush, Avi
DOI：
10.1007/bf01133388
发表时间：
1986-01-01
期刊：
Journal of In Vitro Fertilization and Embryo Transfer
影响因子：
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作者：
CUMMINS J M;BREEN T M;HENNESSEY J F
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HENNESSEY J F
冷冻胚胎移植周期中子宫内膜厚度对异位妊娠的影响：一项包含 17,244 个妊娠周期的分析
影响因子：
6.7
作者：
Liu, Hongfang;Zhang, Jie;Kuang, Yanping
通讯作者：
Kuang, Yanping