Assessment of Seroconversion to SARS-CoV-2 in a Cohort of Pediatric Kidney Transplant Recipients.
Assessment of Seroconversion to SARS-CoV-2 in a Cohort of Pediatric Kidney Transplant Recipients.
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DOI：
10.3389/fped.2020.601327
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发表时间：
2020
影响因子：
2.6
通讯作者：
Hains DS
中科院分区：
文献类型：
--
作者：
Nailescu C;Khalid M;Wilson AC;Amanat F;Arregui S;Canas J;Hooks J;Krammer F;Schwaderer AL;Hains DS
背景：严重急性呼吸综合征冠状病毒2型(SARS-CoV-2)和相关冠状病毒病2019年(新冠肺炎)的发生，深刻影响了成人肾脏疾病患者。相比之下，儿童实体器官移植接受者，包括儿童肾移植(KT)接受者，似乎没有特别高的感染SARS-CoV-2或严重新冠肺炎疾病的风险。这些患者群体可能会受到某些机制的保护，例如具有抗炎特性的免疫抑制药物，或者仅仅是精通自我保护技术。评估SARS-CoV-2抗体血清可能有助于理解为什么这一患者群体显然没有经历严重的SARS-CoV-2临床病程。目的：检测儿童肾移植受者中SARS-CoV-2的血清学状况。方法：采用3种不同方法对2020年5~6月常规门诊就诊的KT患儿进行SARS-CoV-2抗S-CoV-2抗体检测。SARS-CoV-2抗体阳性者占2/3，弱阳性/不确定者占1/3。结果：共评估31例患者(约占我所儿科KT人群的1/3)。1名患者血清转换，3名患者被认为是弱阳性/不确定。无一例出现症状，无一例鼻咽聚合酶链式反应证实为SARS-CoV-2。结论：SARS-CoV-2血清转换在该人群中很少见，可能反映了这些患者实行的社会疏远。这一结果将作为未来纵向研究的基础，以评估抗体在该人群中的长期出现和持续，并可能为未来疫苗反应的研究提供信息。
Background: The occurrence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the associated coronavirus disease 2019 (COVID-19) have profoundly affected adult kidney disease patients. In contrast, pediatric solid organ transplant recipients, including pediatric kidney transplant (KT) recipients, do not seem to be at particularly higher risk for SARS-CoV-2 infection or for severe COVID-19 disease. This patient population might be protected by certain mechanisms, such as the immunosuppressive medications with their anti-inflammatory properties or simply being well-versed in self-protection techniques. Assessing SARS-CoV-2 antibody serologies could potentially help understand why this patient population is apparently spared from severe SARS-CoV-2 clinical courses. Objective: To examine SARS-CoV-2 serologic status in a cohort of pediatric KT recipients. Methods: SARS-CoV-2 anti-spike IgG and IgM antibodies were measured by three different methods in pediatric KT recipients coming for routine clinic visits immediately post-confinement in May-June of 2020. The patients were considered seroconverted if SARS-CoV-2 antibodies were positive by 2/3 methods and weak positive/indeterminate if positive by 1/3. Results: Thirty-one patients were evaluated (about 1/3 of our institution's pediatric KT population). One patient seroconverted, while three were considered weak positive/indeterminate. None were symptomatic and none had nasopharyngeal PCR confirmed SARS-CoV-2 disease. Conclusions: Seroconversion to SARS-CoV-2 was rare in this population and likely reflects the social distancing practiced by these patients. The results will serve as a foundation for a future longitudinal study to evaluate the long-term emergence and persistence of antibodies in this population and may inform studies of response to a future vaccine.
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DOI：
10.1093/jpids/piaa095
发表时间：
2020-11-01
影响因子：
3.2
作者：
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影响因子：
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通讯作者：
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影响因子：
8.8
作者：
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作者：
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DOI：
10.1098/rspb.2014.3085
发表时间：
2015-12-22
期刊：
Proceedings. Biological sciences
影响因子：
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