Paraoxonase-1 (PON1) rs662 Polymorphism and Its Association with Serum Lipid Levels and Longevity in the Bama Zhuang Population.
Paraoxonase-1 (PON1) rs662 Polymorphism and Its Association with Serum Lipid Levels and Longevity in the Bama Zhuang Population.
复制标题
巴马壮族对氧磷酶-1 (PON1) rs662 多态性及其与血脂水平和寿命的关系。
DOI：
10.12659/msm.898231
复制
发表时间：
2016-12-27
期刊：
影响因子：
--
通讯作者：
Zhang Z
中科院分区：
文献类型：
--
作者：
Li Y;Liang G;Shi L;Liang X;Long B;Qin J;Zhang Z
本研究旨在确定巴马壮族人群中 PON1 rs662 多态性与血脂水平和人类寿命的关系。采用Taqman SNP基因分型法对巴马县110名长寿居民（长寿组，年龄90-110岁）、巴马县110名健康居民（对照1组，年龄43-82岁）和南丹县110名无长寿家族史的健康居民（对照2组，年龄28-82岁）进行PON1基因型测定。长寿组BMI（体重指数）和TG（血清总甘油三酯）水平低于两个对照组，而长寿组血清LDL-c（低密度脂蛋白胆固醇）和HDL-c（高密度脂蛋白胆固醇）含量以及SBP（收缩压）和DBP（舒张压）水平高于两个对照组 在两个对照组中（p<0.01）。长寿组和对照组2组之间观察到三种基因型（GG、AG和AA）频率存在显着差异（χ2=15.190，p=0.001）。长寿组中 rs662 的次要等位基因频率 (MAF) 显着高于两个对照组。长寿组的 HDL-c 水平在三种基因型之间存在差异（p<0.05）。 GG和GG+AG基因型的TG水平存在显着差异，而AG和GG+AG基因型的TC（总胆固醇）和HDL-c水平在三组之间存在显着差异（p<0.05）。血脂参数与多种环境因素相关，包括年龄、性别、舒张压、收缩压和体重指数。 PON1 rs662 多态性与血脂水平的关联在三组中不同。 PON1多态性可能是巴马壮族人群长寿的遗传因素之一。 PON1 rs662 SNP（单核苷酸多态性）与长寿组的血清 HDL-c 水平相关。
The present study was performed to identify the association of PON1 rs662 polymorphism with serum lipid levels and human longevity in the Bama Zhuang population. PON1 genotypes were determined by Taqman SNP Genotyping Assays in 110 long-lived inhabitants (longevity group, aged 90–110 years), 110 healthy inhabitants in Bama County (control 1 group, aged 43–82 years) and 110 healthy inhabitants in Nandan County (control 2 group, aged 28–82 years) without family history of longevity. BMI (body mass index) and TG (serum total triglyceride) level were lower in the longevity group than in the two control groups, while the contents of serum LDL-c (low-density lipoprotein cholesterol) and HDL-c (high-density lipoprotein cholesterol) and the levels of SBP (systolic blood pressure) and DBP (diastolic blood pressure) in the longevity group were higher than in the two control groups (p<0.01). Significant differences in the frequencies of three genotypes (GG, AG, and AA) were observed between the longevity group and control 2 group (χ2=15.190, p=0.001). The minor allele frequency (MAF) of rs662 was significantly higher in the longevity group than in the two control groups. The levels of HDL-c in the longevity group were different among the three genotypes (p<0.05). The levels of TG for GG and GG+AG genotypes were significantly different, while the levels of TC (total cholesterol) and HDL-c for AG and GG+AG genotypes were significantly different among the three groups (p<0.05). Serum lipid parameters were correlated with several environmental factors, including age, gender, DBP, SBP, and BMI. The association of PON1 rs662 polymorphism and serum lipid levels was different among the three groups. PON1 polymorphism might be one of the genetic factors of longevity in the Bama Zhuang population. The PON1 rs662 SNP (single nucleotide polymorphism) was associated with serum HDL-c levels in the longevity group.
登录
查看更多内容
影响因子：
3.9
作者：
Campo, S;Sardo, MA;Saitta, A
通讯作者：
Saitta, A
影响因子：
7.4
作者：
Aviram, M;Rosenblat, M;La Du, B
通讯作者：
La Du, B
影响因子：
5.6
作者：
Kontush A
通讯作者：
Kontush A
DOI：
10.1073/pnas.1936249100
发表时间：
2003-11-25
影响因子：
11.1
作者：
Geesaman, BJ;Benson, E;Puca, AA
通讯作者：
Puca, AA
影响因子：
13.6
作者：
Banerjee, Indranil
通讯作者：
Banerjee, Indranil