7.0T ultrahigh-field MRI directly visualized the pedunculopontine nucleus in Parkinson's disease patients
7.0T ultrahigh-field MRI directly visualized the pedunculopontine nucleus in Parkinson's disease patients
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7.0T超高场MRI直接可视化帕金森病患者桥脚核
DOI：
10.6061/clinics/2019/e573
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发表时间：
2019-04
期刊：
影响因子：
2.7
通讯作者：
Yuqing Zhang
中科院分区：
文献类型：
--
作者：
Jiawei Wang;Fei Cong;Yan Zhuo;Lin Chen;Bo Wang;Yuqing Zhang
目的：脚桥核（PPN）被认为是一个有前途的新目标，神经刺激帕金森氏病（PD）患者的姿势不稳定和步态障碍，是难治性的其他治疗方式。然而，PPN通常难以在临床场强下用磁共振成像（MRI）可视化，这极大地限制了PPN作为脑深部电刺激（DBS）的可行手术靶点。因此，本研究的目的是基于7.0T超高场MRI直接可视化PPN。方法：5例PD患者入组，在7.0T超高场MRI扫描仪上使用MP2 MRI序列进行扫描。然后，将MP2序列导入市售导航系统。在导航系统中记录直接定位的PPN极相对于前连合-后连合平面的坐标。研究结果：我们的结果表明，在7.0T超高场MR图像上，PD患者的PPN与周围结构（如导水管周围灰质低信号和邻近白色物质束高信号）相比呈中等信号强度。PPN的头极和尾极相对于后连合的平均坐标分别为6.50 mm和7.20 mm，1.58 mm和2.21 mm，8.89 mm和13.83 mm。结论：我们的研究结果首次提供了在7.0T超高场MRI上使用MP2 MRI序列直接可视化PPN的方法，这可能会提高PPN立体定向靶向的准确性，并改善接受DBS的患者的结局。
OBJECTIVES: The pedunculopontine nucleus (PPN) is considered a promising new target for neurostimulation in Parkinson's disease (PD) patients with postural instability and gait disturbance that is refractory to other treatment modalities. However, the PPN is typically difficult to visualize with magnetic resonance imaging (MRI) at clinical field strengths, which greatly limits the PPN as a viable surgical target for deep brain stimulation (DBS). Thus, the aim of this study is to directly visualize the PPN based on 7.0T ultrahigh-field MRI. METHODS: Five PD patients were enrolled and scanned using the MP2RAGE sequence on a 7.0T ultrahigh-field MRI scanner. Then, the MP2RAGE sequences were imported into a commercially available navigation system. The coordinates of the directly localized PPN poles were recorded in the navigation system relative to the anterior commissure-posterior commissure plane. RESULTS: Our results indicated that the PPN presented intermediate signal intensity in the 7.0T ultrahigh-field MR images in comparison with the surrounding structure, such as the hypo-intensity of the periaqueductal gray and the hyperintensity of the neighboring white matter tracts, in PD patients. The mean coordinates for the rostral and caudal poles of PPN were 6.50 mm and 7.20 mm lateral, 1.58 mm and 2.21 mm posterior, and 8.89 mm and 13.83 mm relative to the posterior commissure. CONCLUSION: Our findings provide, for the first time, direct visualization of the PPN using the MP2RAGE sequence on a 7.0T ultrahigh-field MRI, which may improve the accuracy of stereotactic targeting of the PPN and improve the outcomes in patients undergoing DBS.
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使用 7 特斯拉磁共振成像直接可视化帕金森病的深部脑刺激目标。
影响因子：
4.1
作者：
Cho ZH;Min HK;Oh SH;Han JY;Park CW;Chi JG;Kim YB;Paek SH;Lozano AM;Lee KH
通讯作者：
Lee KH
影响因子：
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影响因子：
14.5
作者：
Ferraye, M. U.;Debu, B.;Pollak, P.
通讯作者：
Pollak, P.
影响因子：
14.5
作者：
Stefani, Alessandro;Lozano, Andres M.;Mazzone, Paolo
通讯作者：
Mazzone, Paolo
影响因子：
2.9
作者：
Plantinga BR;Temel Y;Roebroeck A;Uludağ K;Ivanov D;Kuijf ML;Ter Haar Romenij BM
通讯作者：
Ter Haar Romenij BM