Serum Interleukin-4 and Total Immunoglobulin E in Nonatopic Alopecia Areata Patients and HLA-DRB1 Typing.
Serum Interleukin-4 and Total Immunoglobulin E in Nonatopic Alopecia Areata Patients and HLA-DRB1 Typing.
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DOI：
10.1155/2010/503587
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发表时间：
2010
影响因子：
1.5
通讯作者：
Sefin A
中科院分区：
文献类型：
--
作者：
Attia EA;El Shennawy D;Sefin A
背景。白细胞介素-4 （IL-4）是一种Th2细胞因子，可刺激免疫球蛋白E （IgE）转录。以前没有研究评估非特应性AA患者血清IgE升高的遗传机制。目标。比较埃及非特应性AA患者与健康人血清IL-4和总IgE水平，探讨其与HLA-DRB1等位基因的可能关系。结果。采用ELISA法检测40例对照组和54例非特应性AA患者血清IL-4和总IgE水平。通过序列特异性寡核苷酸探针技术将患者HLA-DRB1分型与正常埃及人群进行比较。我们发现AA患者（特别是普遍秃、AU和慢性患者）血清IL-4和总IgE显著升高（P < 0.01）。HLA-DRB1*11是一种一般易感/慢性等位基因。DRB1*13是一个保护性等位基因。DRB1*01和DRB1*07与慢性相关。局部AA表现为DRB1*03和DRB1*07降低。广泛型表现为DRB1*08升高，DRB1*04降低。在DRB1*07和DRB1*11患者中观察到IL4和IgE升高，而不是DRB1*04患者。结论。血清IL-4和IgE在非特应性AA患者中升高，特别是AU和慢性疾病。相关的易感性、慢性性和严重程度HLADRB1等位基因可能决定AA免疫反应的类型、强度和持续时间，有利于il - 4和IgE升高。
Background. Interleukin-4 (IL-4), a Th2 cytokine, can stimulate immunoglobulin E (IgE) transcription. No previous studies evaluated the genetic mechanisms in nonatopic AA patients with elevated serum IgE. Objective. To compare serum IL-4 and total IgE levels between Egyptian nonatopic AA patients and healthy subjects and to investigate a possible relation to HLA-DRB1 alleles. Results. Serum IL-4 and total IgE were measured by ELISA in 40 controls and 54 nonatopic AA patients. Patients' HLA-DRB1 typing by sequence specific oligonucleotide probe technique was compared to normal Egyptian population. We found significantly elevated serum IL-4 and total IgE in AA patients (particularly alopecia universalis, AU, and chronic patients) (P < .01). HLA-DRB1*11 is a general susceptibility/chronicity allele. DRB1*13 is a protective allele. DRB1*01 and DRB1*07 are linked to chronicity. Localized AA showed decreased DRB1*03 and DRB1*07. Extensive forms showed increased DRB1*08 and decreased DRB1*04. Elevated IL4 and IgE were observed in patients with DRB1*07 and DRB1*11 not DRB1*04. Conclusion. Serum IL-4 and IgE are elevated in nonatopic AA patients, particularly AU and chronic disease. Relevant susceptibility, chronicity, and severity HLADRB1 alleles may have a role in determining type, magnitude, and duration of immune response in AA favouring increased IL4 and IgE.
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影响因子：
6.5
作者：
Hedstrand, H;Perheentupa, J;Kämpe, O
通讯作者：
Kämpe, O
影响因子：
6.5
作者：
HOFFMANN, R;WENZEL, E;HAPPLE, R
通讯作者：
HAPPLE, R
影响因子：
3
作者：
Katagiri, Kazumoto;Arakawa, Shoko;Hatano, Yutaka
通讯作者：
Hatano, Yutaka
DOI：
10.1159/000248775
发表时间：
1987-07-01
期刊：
DERMATOLOGICA
影响因子：
--
作者：
ORECCHIA, G;BELVEDERE, MC;RABBIOSI, G
通讯作者：
RABBIOSI, G
DOI：
10.3949/ccjm.53.2.189
发表时间：
1986-06-01
期刊：
CLEVELAND CLINIC QUARTERLY
影响因子：
--
作者：
MIKESELL, JF;BERGFELD, WF;BRAUN, WF
通讯作者：
BRAUN, WF