Emergence of Usutu virus, an African mosquito-borne flavivirus of the Japanese encephalitis virus group, central Europe.

Emergence of Usutu virus, an African mosquito-borne flavivirus of the Japanese encephalitis virus group, central Europe.
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DOI:
10.3201/eid0807.020094
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发表时间:
2002-07
影响因子:
11.8
通讯作者:
Nowotny N
Nowotny N
中科院分区:
医学2区
文献类型:
--
作者:
Weissenböck H;Kolodziejek J;Url A;Lussy H;Rebel-Bauder B;Nowotny N

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2001年夏末,奥地利发生了几种鸟类的一系列死亡事件,类似于美国西尼罗河病毒(WNV)疫情的开始。我们对死鸟进行了尸检,并用各种方法进行了检查;病理和免疫组织学检查表明是西尼罗河病毒感染。随后,病毒被分离、鉴定、部分测序并进行系统发育分析。这些分离株与Usutu病毒(USUV)有97%的同源性,USUV是一种蚊媒传播的日本脑炎病毒组黄病毒;USUV以前从未在非洲以外发现过,也从未与动物或人类的致命疾病有关。如果在中欧建立这种病毒,可能会对禽类种群产生相当大的影响;USUV是否有可能导致严重的人类疾病尚不清楚。
During late summer 2001 in Austria, a series of deaths in several species of birds occurred, similar to the beginning of the West Nile virus (WNV) epidemic in the United States. We necropsied the dead birds and examined them by various methods; pathologic and immunohistologic investigations suggested a WNV infection. Subsequently, the virus was isolated, identified, partially sequenced, and subjected to phylogenetic analysis. The isolates exhibited 97% identity to Usutu virus (USUV), a mosquito-borne Flavivirus of the Japanese encephalitis virus group; USUV has never previously been observed outside Africa nor associated with fatal disease in animals or humans. If established in central Europe, this virus may have considerable effects on avian populations; whether USUV has the potential to cause severe human disease is unknown.
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