Differential propensity of dissection along the aorta.
Differential propensity of dissection along the aorta.
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DOI：
10.1007/s10237-021-01418-8
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发表时间：
2021-06
影响因子：
3.5
通讯作者：
Humphrey JD
中科院分区：
文献类型：
--
作者：
Ban E;Cavinato C;Humphrey JD
主动脉夹层的进展，部分是由于壁的分层。先前对主动脉切开段的实验表明，注入壁内的流体以两种不同的模式使主动脉分层：腹主动脉中的逐步渐进撕裂和胸主动脉中更普遍的突然撕裂模式，其也可以在其他区域表现出来。描述这两种撕裂模式的微观结构理解仍然缺乏。我们实现了相场有限元模型的主动脉壁，部分动机双光子成像，并发现相关关系的最大压力撕裂前作为局部几何形状和材料特性的函数。具体而言，撕裂的压力的平方直接关系到组织的硬度和撕裂的临界能量和相反的平方根撕裂面积;这种相关性解释了撕裂的突然模式，并与显微镜，提出了渐进撕裂的机制。显微镜检查还证实，厚的层间径向支柱在主动脉腹部区域更丰富，之前在该区域观察到进行性撕裂。计算结果表明，结构上显着的径向支柱通过两种机制增加撕裂压力：限制流体作为流动的障碍，并通过保持相邻lamellae在一起，增加组织刚度。总的来说，这两个相场模型提供了新的见解的机械因素，可以影响壁内分层，促进主动脉夹层。
Aortic dissections progress, in part, by delamination of the wall. Previous experiments on cut-open segments of aorta demonstrated that fluid injected within the wall delaminates the aorta in two distinct modes: step-wise progressive tearing in the abdominal aorta and a more prevalent sudden mode of tearing in the thoracic aorta that can also manifest in other regions. A microstructural understanding that delineates these two modes of tearing has remained wanting. We implemented a phase-field finite element model of the aortic wall, motivated in part by two-photon imaging, and found correlative relations for the maximum pressure prior to tearing as a function of local geometry and material properties. Specifically, the square of the pressure of tearing relates directly to both tissue stiffness and the critical energy of tearing and inversely to the square root of the torn area; this correlation explains the sudden mode of tearing and, with the microscopy, suggests a mechanism for progressive tearing. Microscopy also confirmed that thick interlamellar radial struts are more abundant in the abdominal region of the aorta, where progressive tearing was observed previously. The computational results suggest that structurally significant radial struts increase tearing pressure by two mechanisms: confining the fluid by acting as barriers to flow and increasing tissue stiffness by holding the adjacent lamellae together. Collectively, these two phase-field models provide new insights into the mechanical factors that can influence intramural delaminations that promote aortic dissection.
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影响因子：
1.7
作者：
Humphrey JD
通讯作者：
Humphrey JD
影响因子：
3.5
作者：
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