Feasibility of autologous cord blood cells for infants with hypoxic-ischemic encephalopathy.
Feasibility of autologous cord blood cells for infants with hypoxic-ischemic encephalopathy.
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DOI：
10.1016/j.jpeds.2013.11.036
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发表时间：
2014-05
期刊：
影响因子：
--
通讯作者：
Kurtzberg J
中科院分区：
文献类型：
--
作者：
Cotten CM;Murtha AP;Goldberg RN;Grotegut CA;Smith PB;Goldstein RF;Fisher KA;Gustafson KE;Waters-Pick B;Swamy GK;Rattray B;Tan S;Kurtzberg J
目的探讨为新生儿缺氧缺血性脑病(HIE)提供自体脐血(UCB)细胞的可行性和安全性。我们在重症监护托儿所登记了因HIE而冷却并有可用的脐带血的婴儿，进行了一项关于非循环保存的自体体积和红细胞减少的脐带血细胞的开放标签研究(根据体积和红细胞含量调整最多四剂，1-5×107细胞/剂量)。记录脐血采集、细胞输注特征、输注前后生命体征。作为探索性分析，我们将细胞接受者的住院结果(死亡率、出院时的口服喂养)和一年存活率与贝利III在3个领域(认知、语言和运动发育)的≥85评分与没有可用细胞的冷冻儿进行了比较。23名婴儿接受了降温和细胞移植。中位采集量和输液量分别为36和4.3毫升。在出生后48小时内，包括血氧饱和度在内的生命体征在输液前后相似。接受细胞移植的婴儿和同时降温的婴儿的住院结果相似。18例细胞移植受者中有13例(74%)和46例合并冷冻儿中有19例(41%)存活，这些婴儿的1年预后已知，≥评分为85。采集、制备和输注新鲜的自体脐血细胞用于治疗新生儿缺氧缺血性脑病是可行的。需要一项随机双盲研究。
To assess feasibility and safety of providing autologous umbilical cord blood (UCB) cells to neonates with hypoxic-ischemic encephalopathy (HIE). We enrolled infants in the Intensive Care Nursery who were cooled for HIE and had available UCB in an open-label study of non-cyropreserved autologous volume- and red blood cell-reduced UCB cells (up to four doses adjusted for volume and RBC content,1 – 5 × 107cells/dose). We recorded UCB collection and cell infusion characteristics, and pre- and post- infusion vital signs. As exploratory analyses we compared cell recipients’ hospital outcomes (mortality, oral feeds at discharge) and one year survival with Bayley III scores ≥ 85 in 3 domains (cognitive, language, and motor development) with cooled infants who did not have available cells. Twenty-three infants were cooled and received cells. Median collection and infusion volumes were 36 and 4.3 milliliters. Vital signs including oxygen saturation were similar before and after infusions in the first 48 postnatal hours. Cell recipients and concurrent cooled infants had similar hospital outcomes. Thirteen of 18 (74%) cell recipients and 19 of 46 (41%) concurrent cooled infants with known 1 year outcomes survived with scores ≥ 85. Collection, preparation and infusion of fresh autologous UCB cells for use in infants with HIE is feasible. A randomized double-blind study is needed.
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影响因子：
3.7
作者：
Donega V;van Velthoven CT;Nijboer CH;van Bel F;Kas MJ;Kavelaars A;Heijnen CJ
通讯作者：
Heijnen CJ
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3.7
作者：
Geissler M;Dinse HR;Neuhoff S;Kreikemeier K;Meier C
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Meier C
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168.9
作者：
Gluckman, PD;Wyatt, JS;Gunn, AJ
通讯作者：
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影响因子：
15.9
作者：
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通讯作者：
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影响因子：
4
作者：
Pimentel-Coelho, Pedro M.;Magalhaes, Elizabeth S.;Mendez-Otero, Rosalia
通讯作者：
Mendez-Otero, Rosalia