Potential Role of Heterocyclic Aromatic Amines in Neurodegeneration.
Potential Role of Heterocyclic Aromatic Amines in Neurodegeneration.
复制标题
DOI：
10.1021/acs.chemrestox.1c00274
复制
发表时间：
2022-01-17
影响因子：
4.1
通讯作者：
Cannon JR
中科院分区：
文献类型：
--
作者：
Syeda T;Cannon JR
杂环芳胺(HAAs)主要存在于肉类高温蒸煮的热解过程中。肉类消费是西方饮食中非常典型的，而东方国家的肉类消费量正在迅速增长；哈斯代表着广泛的接触。HAAs被归类为可能的人类致癌物质；许多流行病学研究表明，经常食用含有HAAs的肉类是癌症的危险因素。具体的Haa受到了极大的关注。例如，2-氨基-1-甲基-6-苯基咪唑并[4，5-b]吡啶作为一种遗传毒物和诱变剂已被广泛研究，并有关于神经毒性的新文献。Harmane在特发性震颤和潜在的帕金森病(PD)中的作用已被广泛研究。已经证明，在特发性震颤患者的血液和大脑中，Harmane水平升高。食用肉类与神经退行性疾病的病因学有关；然而，在肉类准备过程中形成的有毒物质的作用尚未被研究。流行病学研究目前正在研究HAAs与神经退行性疾病(如特发性震颤和帕金森病)风险之间的联系。我们实验室和其他实验室的研究提供了强有力的证据，表明HAA暴露在细胞和动物模型中会产生帕金森病和阿尔茨海默病相关的神经毒性。在这篇综述中，我们总结并批判性地评价了HAA诱导的神经毒性以及HAAs潜在神经毒性作用的分子基础的研究。现有研究有力地支持了这一假设，即HAAs可能影响神经功能，解决对不良神经后果的理解差距对于确定这些化合物是否为可改变的危险因素至关重要。
Heterocyclic aromatic amines (HAAs) are mainly formed in the pyrolysis process during high-temperature cooking of meat. Meat consumption is very typical of the western diet, and the amount of meat consumption in the eastern countries is growing rapidly; HAAs represents widespread exposure. HAAs are classified as possible human carcinogens; numerous epidemiological studies have demonstrated regular consumption of meat with HAAs as risk factor for cancers. Specific HAAs have received major attention. For example, 2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine has been extensively studied as a genotoxicant and mutagen, with emergent literature on neurotoxicity. Harmane has been extensively studied for a role in essential tremors and potentially Parkinson’s disease (PD). Harmane levels have been demonstrated to be elevated in blood and brain in essential tremor patients. Meat consumption has been implicated in the etiology of neurodegenerative diseases; however, the role of toxicants formed during meat preparation has not been studied. Epidemiological studies are currently examining the association between HAAs and risk of neurodegenerative diseases such as essential tremors and PD. Studies from our laboratory and others have provided strong evidence that HAA exposure produces PD and Alzheimer’s disease-relevant neurotoxicity in cellular and animal models. In this review, we summarize and critically evaluate previous studies on HAA-induced neurotoxicity and the molecular basis of potential neurotoxic effects of HAAs. The available studies provide strong support for the premise that HAAs may impact neurological function and that addressing gaps in understanding of adverse neurological outcomes is critical to determine whether these compounds are modifiable risk factors.
登录
查看更多内容
影响因子：
11.2
作者：
Chen, HL;Zhang, SMM;Ascherio, A
通讯作者：
Ascherio, A
影响因子：
3.8
作者：
Cannon, Jason R.;Greenamyre, J. Timothy
通讯作者：
Greenamyre, J. Timothy
DOI：
10.1073/pnas.87.23.9368
发表时间：
1990-12-01
影响因子：
11.1
作者：
ALBORES, R;NEAFSEY, EJ;COLLINS, MA
通讯作者：
COLLINS, MA
影响因子：
8.8
作者：
Bula, Maria;Przybylski, Wieslaw;Kajak-Siemaszko, Katarzyna
通讯作者：
Kajak-Siemaszko, Katarzyna
影响因子：
4.7
作者：
Adell, A;Biggs, TA;Myers, RD
通讯作者：
Myers, RD