The arcuate nucleus as a primary site of satiety effect of leptin in rats
The arcuate nucleus as a primary site of satiety effect of leptin in rats
复制标题
弓状核是瘦素对大鼠饱腹感作用的主要部位
DOI：
10.1016/s0304-3940(97)00163-8
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发表时间：
1997
影响因子：
2.5
通讯作者：
K. Nakao
中科院分区：
文献类型：
--
作者：
N. Satoh;Y. Ogawa;G. Katsuura;M. Hayase;T. Tsuji;K. Imagawa;Y. Yoshimasa;S. Nishi;K. Hosoda;K. Nakao
肥胖(Ob)基因编码一种脂肪细胞衍生的循环饱足因子(Leptin)，该因子参与能量平衡的调节。在本研究中，我们考察了I.C.V.的效果。注射重组人瘦素对大鼠摄食量和体重增加的影响。我们还研究了将瘦素直接微量注射到弓状核(Arc)、下丘脑腹内侧核(VMH)和下丘脑外侧核(Lh)的效果。一次单独的静脉注射。注射重组人瘦素(0.252.0μg/只)可显著减少大鼠的摄食量和体重增加，并呈剂量依赖关系。双侧Arc、Vmh和Lh内微量注射(0.125-0.5μg/部位)导致摄食量和体重增加与剂量相关，与按药效顺序的赋形剂处理组相比；Arc&Gt；Vmh=Lh。本研究提供了第一个直接证据，证明Arc是瘦素饱腹感的主要作用部位。
The obese (ob) gene encodes a fat cell-derived circulating satiety factor (leptin) that is involved in the regulation of energy homeostasis. In the present study, we examined effects of i.c.v. injection of recombinant human leptin on food intake and body weight gain in rats. We also studied effects of direct microinjections of leptin into the arcuate nucleus (Arc), ventromedial hypothalamus (VMH), and lateral hypothalamus (LH). A single i.c.v. injection of recombinant human leptin (0.25–2.0 μg/rat) reduced significantly and dose-dependently food intake and body weight gain in rats. Microinjections (0.125–0.5 μg/site) into the bilateral Arc, VMH, and LH caused dose-related decreases in food intake and body weight gain as compared with vehicle-treated groups with a rank order of potency; Arc>VMH=LH. The present study provides the first direct evidence that the Arc is a primary site of satiety effect of leptin.
影响因子：
56.9
作者：
HALAAS, JL;GAJIWALA, KS;FRIEDMAN, JM
通讯作者：
FRIEDMAN, JM
影响因子：
158.5
作者：
Considine, RV;Sinha, MK;Caro, JF
通讯作者：
Caro, JF