Aminode: Identification of Evolutionary Constraints in the Human Proteome.
Aminode: Identification of Evolutionary Constraints in the Human Proteome.
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Aminode：人类蛋白质组进化约束的识别。
DOI：
10.1038/s41598-018-19744-w
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发表时间：
2018-01-22
影响因子：
4.6
通讯作者：
Sardiello M
中科院分区：
文献类型：
--
作者：
Chang KT;Guo J;di Ronza A;Sardiello M
Evolutionarily constrained regions (ECRs) are a hallmark for sites of critical importance for a protein’s structure or function. ECRs can be inferred by comparing the amino acid sequences from multiple protein homologs in the context of the evolutionary relationships that link the analyzed proteins. The compilation and analysis of the datasets required to infer ECRs, however, are time consuming and require skills in coding and bioinformatics, which can limit the use of ECR analysis in the biomedical community. Here, we developed Aminode, a user-friendly webtool for the routine and rapid inference of ECRs. Aminode is pre-loaded with the results of the analysis of the whole human proteome compared with proteomes from 62 additional vertebrate species. Profiles of the relative rates of amino acid substitution and ECR maps of human proteins are available for immediate search and download on the Aminode website. Aminode can also be used for custom analyses of protein families of interest. Interestingly, mapping of known missense variants shows great enrichment of pathogenic variants and depletion of non-pathogenic variants in Aminode-generated ECRs, suggesting that ECR analysis may help evaluate the potential pathogenicity of variants of unknown significance. Aminode is freely available at http://www.aminode.org.
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DOI：
10.1016/j.bbadis.2015.05.011
发表时间：
2015-10
期刊：
Biochimica et biophysica acta
影响因子：
--
作者：
Mole SE;Cotman SL
通讯作者：
Cotman SL
DOI：
10.1073/pnas.89.22.10915
发表时间：
1992-11-15
影响因子：
11.1
作者：
HENIKOFF, S;HENIKOFF, JG
通讯作者：
HENIKOFF, JG
影响因子：
--
作者：
Jackson, Pilgrim J.;Douglas, Nick R.;Millhauser, Glenn L.
通讯作者：
Millhauser, Glenn L.
影响因子：
4.8
作者：
Miller, AJ;Levy, C;Fisher, DE
通讯作者：
Fisher, DE
影响因子：
7
作者：
Binkley, Jonathan;Karra, Kalpana;Sidow, Arend
通讯作者：
Sidow, Arend