Reading and language disorders: the importance of both quantity and quality.
Reading and language disorders: the importance of both quantity and quality.
复制标题
阅读和语言障碍：数量和质量的重要性。
DOI：
10.3390/genes5020285
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发表时间：
2014-04-04
期刊：
影响因子：
3.5
通讯作者：
Paracchini S
中科院分区：
文献类型：
--
作者：
Newbury DF;Monaco AP;Paracchini S
阅读障碍和语言障碍是常见的儿童疾病，它们经常相互共存，并与其他神经发育障碍共存。有强有力的证据表明，障碍，如阅读障碍和特定语言障碍（SLI），有一个遗传基础，但我们预计，贡献的遗传因素是复杂的性质。到目前为止，只有少数基因与这些特征有关。它们的功能特征为神经发育障碍的生物学提供了新的见解。然而，由于缺乏生物标记物和明确的诊断标准，无法收集强大的全基因组筛选所需的大样本量。该领域的主要挑战之一将是在多学科合作中将联合收割机仔细的临床评估与高通量遗传技术相结合。
Reading and language disorders are common childhood conditions that often co-occur with each other and with other neurodevelopmental impairments. There is strong evidence that disorders, such as dyslexia and Specific Language Impairment (SLI), have a genetic basis, but we expect the contributing genetic factors to be complex in nature. To date, only a few genes have been implicated in these traits. Their functional characterization has provided novel insight into the biology of neurodevelopmental disorders. However, the lack of biological markers and clear diagnostic criteria have prevented the collection of the large sample sizes required for well-powered genome-wide screens. One of the main challenges of the field will be to combine careful clinical assessment with high throughput genetic technologies within multidisciplinary collaborations.
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影响因子：
3.7
作者：
Adler WT;Platt MP;Mehlhorn AJ;Haight JL;Currier TA;Etchegaray MA;Galaburda AM;Rosen GD
通讯作者：
Rosen GD
影响因子：
2.5
作者：
Badcock, Nicholas A.;Bishop, Dorothy V. M.;Hardiman, Mervyn J.;Barry, Johanna G.;Watkins, Kate E.
通讯作者：
Watkins, Kate E.
DOI：
10.1044/1092-4388(2001/072
发表时间：
2001-08-01
影响因子：
2.6
作者：
Bedore, LM;Leonard, LB
通讯作者：
Leonard, LB
DOI：
10.1126/science.1230531
发表时间：
2013-06-14
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Bishop DV
通讯作者：
Bishop DV
影响因子：
4.5
作者：
Brandler WM;Morris AP;Evans DM;Scerri TS;Kemp JP;Timpson NJ;St Pourcain B;Smith GD;Ring SM;Stein J;Monaco AP;Talcott JB;Fisher SE;Webber C;Paracchini S
通讯作者：
Paracchini S