Co-localisation of abnormal brain structure and function in specific language impairment.
Co-localisation of abnormal brain structure and function in specific language impairment.
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DOI：
10.1016/j.bandl.2011.10.006
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发表时间：
2012-03
影响因子：
2.5
通讯作者：
Watkins, Kate E.
中科院分区：
文献类型：
--
作者：
Badcock, Nicholas A.;Bishop, Dorothy V. M.;Hardiman, Mervyn J.;Barry, Johanna G.;Watkins, Kate E.
关键词：
比较SLI，未受影响的兄弟姐妹和典型同龄人的大脑结构和功能。左下额叶皮质SLI灰质较多。右侧尾状核和双侧上级颞叶皮质SLI灰质减少。3.采用听觉内隐命名任务检测功能激活。在功能上，SLI减少了左侧下额叶皮层和双侧上级颞叶皮层的激活。我们评估了10名特定语言障碍（SLI）患者的大脑结构和功能之间的关系，并与6名未受影响的兄弟姐妹和16名具有典型语言的无关对照参与者进行了比较。基于体素的形态测量表明，灰质在SLI组，相对于对照组，增加了左下额叶皮质和减少在右侧尾状核和上级颞叶皮质双边。与对照组相比，未受影响的兄弟姐妹的尾状核灰质也减少了。在听觉内隐命名任务中，SLI组的左侧下额叶皮层、右侧壳核和双侧上级颞叶皮层的激活减少。尽管在空间上一致的结构和功能异常额和颞区，在这些地区的结构和功能之间的关系是不同的。这些研究结果表明，SLI的多种结构和功能异常与接受性和表达性语言处理不同。
► Compared brain structure and function in SLI, unaffected siblings, and typical peers. ► More grey matter in SLI in the left inferior frontal cortex. ► Less grey matter in SLI in the right caudate nucleus and superior temporal cortex bilaterally. ► Functional activation was examined with an auditory covert naming task. ► Functionally, SLI had reduced activation of the left inferior frontal cortex and the superior temporal cortex bilaterally. We assessed the relationship between brain structure and function in 10 individuals with specific language impairment (SLI), compared to six unaffected siblings, and 16 unrelated control participants with typical language. Voxel-based morphometry indicated that grey matter in the SLI group, relative to controls, was increased in the left inferior frontal cortex and decreased in the right caudate nucleus and superior temporal cortex bilaterally. The unaffected siblings also showed reduced grey matter in the caudate nucleus relative to controls. In an auditory covert naming task, the SLI group showed reduced activation in the left inferior frontal cortex, right putamen, and in the superior temporal cortex bilaterally. Despite spatially coincident structural and functional abnormalities in frontal and temporal areas, the relationships between structure and function in these regions were different. These findings suggest multiple structural and functional abnormalities in SLI that are differently associated with receptive and expressive language processing.
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DOI：
10.1073/pnas.0402680101
发表时间：
2004-05-25
影响因子：
11.1
作者：
Gogtay, N;Giedd, JN;Thompson, PM
通讯作者：
Thompson, PM
影响因子：
16.2
作者：
Giedd, Jay N.;Rapoport, Judith L.
通讯作者：
Rapoport, Judith L.
影响因子：
5.2
作者：
Bishop DV
通讯作者：
Bishop DV
影响因子：
11.2
作者：
De Fossé, L;Hodge, SM;Harris, GJ
通讯作者：
Harris, GJ
影响因子：
14.5
作者：
Crinion, J;Price, CJ
通讯作者：
Price, CJ