T1rho (T1ρ) MR imaging in Alzheimer's disease and Parkinson's disease with and without dementia.
T1rho (T1ρ) MR imaging in Alzheimer's disease and Parkinson's disease with and without dementia.
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DOI：
10.1007/s00415-010-5762-6
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发表时间：
2011-03
影响因子：
6
通讯作者：
Borthakur A
中科院分区：
文献类型：
--
作者：
Haris M;Singh A;Cai K;Davatzikos C;Trojanowski JQ;Melhem ER;Clark CM;Borthakur A
在当前的研究中，我们的目标是测量对照组、阿尔茨海默病 (AD)、帕金森病 (PD) 和 PD 痴呆患者 (PDD) 大脑海马体的 T1rho (T1ρ)，并确定 T1ρ 在区分这些群体中的功效。经知情同意，53 名 AD 患者、62 名 PD 患者、11 名 PDD 患者和 46 名年龄匹配的对照者接受了标准化临床评估，包括简易精神状态检查 (MMSE) 和 1.5-T 临床扫描仪上的脑部 T1ρ MRI。 T1ρ 图是通过将每个像素的强度拟合为自旋锁脉冲持续时间的函数来生成的。在对照、AD、PD 和 PDD 中，右侧海马 (RH) 的平均值 ± SE T1ρ 值为 92.15 ± 2.00、99.65 ± 1.98、85.68 ± 1.87、102.47 ± 4.66 ms，而左侧海马 (LH) 的这些值为 90.16 ± 1.82、99.53 ± 1.91、84.33±2.03、95.33±4.64 毫秒。观察到各组之间 RH 和 LHT1ρ 存在显着差异 (p < 0.001)。与对照（p = 0.034，p = 0.001）和 PD（p < 0.001，p < 0.001）相比，AD 中的 RH 和 LHT1ρ 均显着增加。在对照中，与 PD 相比，RH 和 LHT1ρ 值均显着增加（p = 0.031，p = 0.027），而与 PDD 相比，仅 RH T1ρ 值显着降低（p = 0.043）。 PD 中的 RH 和 LH T1ρ 值均显着低于 PDD（p = 0.004，p = 0.032）。 T1ρ 与年龄之间以及 T1ρ 与 MMSE 评分之间未观察到显着相关性。 AD 和 PD 中 T1ρ 的系列测量可以提供疾病进展的性质，并有助于早期诊断。
In the current study, we aim to measure T1rho (T1ρ) in the hippocampus in the brain of control, Alzheimer’s disease (AD), Parkinson’s disease (PD), and PD patients with dementia (PDD), and to determine efficacy of T1ρ in differentiating these cohorts. With informed consent, 53 AD patients, 62 PD patients, 11 PDD patients, and 46 age-matched controls underwent a standardized clinical assessment including mini-mental state examination (MMSE) and brain T1ρ MRI on a 1.5-T clinical-scanner. T1ρ maps were generated by fitting each pixel’s intensity as a function of the spin-lock pulse duration. In control, AD, PD and PDD, mean ± SE T1ρ values in the right hippocampus (RH) were 92.15 ± 2.00, 99.65 ± 1.98, 85.68 ± 1.87, 102.47 ± 4.66 ms while in the left hippocampus (LH) these values were 90.16 ± 1.82, 99.53 ± 1.91, 84.33 ± 2.03, 95.33 ± 4.64 ms. Significant difference for both RH and LH T1ρ across the groups (p < 0.001) was observed. Both RH and LH T1ρ were significantly increased in AD compared to control (p = 0.034, p = 0.001) and PD (p < 0.001, p < 0.001). In control, both RH and LH T1ρ values were significantly increased compared to PD (p = 0.031, p = 0.027) while compared to PDD only the RH T1ρ value was significantly decreased (p = 0.043). Both RH and LH T1ρ values in PD were significantly lower than PDD (p = 0.004, p = 0.032). No significant correlation between the T1ρ and age as well as between T1ρ and MMSE scores was observed. The serial measurement of T1ρ in both AD and PD may provide the nature of disease progression and may contribute to their early diagnosis.
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影响因子：
4.4
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