Gastrins, iron homeostasis and colorectal cancer.
Gastrins, iron homeostasis and colorectal cancer.
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DOI：
10.1016/j.bbamcr.2011.02.007
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发表时间：
2011-05
期刊：
影响因子：
--
通讯作者：
Baldwin GS
中科院分区：
文献类型：
--
作者：
Kovac S;Anderson GJ;Baldwin GS
肽激素胃泌素已被鉴定为酸分泌的主要调节剂和正常和恶性胃肠道细胞的有效有丝分裂原。胃酸在膳食铁吸收中的重要性在50年前首次变得明显，当时缺铁性贫血被认为是胃部分切除术的长期后果。本文综述了循环胃泌素，铁状态和结直肠癌之间的联系。胃泌素以微摩尔亲和力结合两个铁离子，并且在激素的非酰胺化形式的情况下，铁结合对于体外和体内生物活性是必需的。通过生物化学技术证明了胃泌素和转铁蛋白之间的相互作用，从而提出了胃泌素催化铁负载转铁蛋白的建议。一些证据，包括铁超负荷疾病血色素沉着症小鼠和人类循环胃泌素浓度增加以及转铁蛋白饱和度与循环胃泌素浓度呈正相关的事实，表明胃泌素可能参与铁稳态。相反，认识到三价铁离子在胃泌素的生物活性中发挥意想不到的作用，可能有助于开发用于结肠直肠癌和胃肠道粘膜增殖的其他病症的有用疗法。
The peptide hormone gastrin has been identified as a major regulator of acid secretion and a potent mitogen for normal and malignant gastrointestinal cells. The importance of gastric acid in the absorption of dietary iron first became evident 50 years ago when iron-deficiency anemia was recognised as a long-term consequence of partial gastrectomy. This review summarises the connections between circulating gastrins, iron status and colorectal cancer. Gastrins bind two ferric ions with micromolar affinity and, in the case of non-amidated forms of the hormone, iron-binding is essential for biological activity in vitro and in vivo. The demonstration of an interaction between gastrin and transferrin by biochemical techniques led to the proposal that gastrins catalyse the loading of transferrin with iron. Several lines of evidence, including the facts that the concentrations of circulating gastrins are increased in mice and humans with the iron-overload disease hemochromatosis and that transferrin saturation positively correlates with circulating gastrin concentration, suggest the potential involvement of gastrins in iron homeostasis. Conversely, recognition that ferric ions play an unexpected role in the biological activity of gastrins may assist in the development of useful therapies for colorectal carcinoma and other disorders of mucosal proliferation in the gastrointestinal tract.
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影响因子：
24.5
作者：
Brookes, M. J.;Hughes, S.;Tselepis, C.
通讯作者：
Tselepis, C.
影响因子：
29.4
作者：
Friis-Hansen, Lennart;Rieneck, Klaus;Rehfeld, Jens F.
通讯作者：
Rehfeld, Jens F.
影响因子：
29
作者：
Donovan, A;Lima, CA;Andrews, NC
通讯作者：
Andrews, NC
影响因子：
15.9
作者：
COOK, JD;BROWN, GM;VALBERG, LS
通讯作者：
VALBERG, LS
DOI：
10.1098/rspb.1905.0029
发表时间：
1905-08-01
期刊：
PROCEEDINGS OF THE ROYAL SOCIETY OF LONDON SERIES B-CONTAINING PAPERS OF A BIOLOGICAL CHARACTER
影响因子：
--
作者：
Edkins, JS
通讯作者：
Edkins, JS