The Impact of Superoxide Dismutase-1 Genetic Variation on Cardiovascular and All-Cause Mortality in a Prospective Cohort Study: The Yamagata (Takahata) Study.
The Impact of Superoxide Dismutase-1 Genetic Variation on Cardiovascular and All-Cause Mortality in a Prospective Cohort Study: The Yamagata (Takahata) Study.
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DOI：
10.1371/journal.pone.0164732
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Kubota I
中科院分区：
文献类型：
--
作者：
Otaki Y;Watanabe T;Nishiyama S;Takahashi H;Arimoto T;Shishido T;Miyamoto T;Konta T;Shibata Y;Sato H;Kawasaki R;Daimon M;Ueno Y;Kato T;Kayama T;Kubota I
氧化应激是心血管疾病的主要原因。超氧化物歧化酶-1（SOD 1）是一种抗氧化剂，可防止氧化应激。据报道，SOD基因内的脱氧核糖核酸（DNA）变异（如单核苷酸多态性（SNP）或单倍型）与心血管疾病的发生有关。然而，在一般人群中，SOD 1变异性是否与心血管或全因死亡率相关仍有待确定。这项前瞻性队列研究纳入了2799名参与社区健康研究的受试者，随访10年。我们对639个SNPs进行了基因分型，发现SOD 1基因内的SNP rs 1041740和rs 17880487与心血管死亡率相关。随访期间有193例死亡，包括57例心血管死亡。多因素考克斯比例风险回归分析显示，在调整混杂因素后，rs 1041740纯合子T等位基因与全因死亡和心血管死亡相关。通过增加rs 1041740作为心血管危险因素，净重新分类指数得到显著改善。另一方面，在rs 17880487纯合子T等位基因携带者中未观察到心血管死亡。单倍型分析表明，T等位基因rs 1041740和T等位基因rs 17880487的单倍型分别为心血管死亡的增、减易感性，且具有互补的SNP序列。SOD 1基因的变异与一般人群的心血管死亡相关。
Oxidative stress is a major cause of cardiovascular disease. Superoxide dismutase-1 (SOD1) is an antioxidant that protects against oxidative stress. Deoxyribonucleic acid (DNA) variations such as single nucleotide polymorphism (SNP) or haplotypes within the SOD gene are reportedly associated with the development of cardiovascular disease. However, it remains to be determined whether SOD1 variability is associated with cardiovascular or all-cause mortality in the general population. This prospective cohort study included 2799 subjects who participated in a community-based health study with a 10-year follow-up. We genotyped 639 SNPs and found the association of SNP rs1041740 and rs17880487 within a SOD1 gene with cardiovascular mortality. There were 193 deaths during the follow-up period including 57 cardiovascular deaths. Multivariate Cox proportional hazard regression analysis revealed that the homozygous T-allele of rs1041740 was associated with all-cause and cardiovascular deaths after adjusting for confounding factors. The net reclassification index was significantly improved by adding rs1041740 as a cardiovascular risk factor. On the other hand, cardiovascular death was not observed in homozygous T-allele carriers of rs17880487. Haplotype analysis identified the haplotype with T-allele of rs1041740 and that with T-allele of rs17880487 as increasing and decreasing susceptibility for cardiovascular mortality, and it had complementary SNP sequences. Variation in the SOD1 gene was associated with cardiovascular deaths in the general population.
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影响因子：
5.3
作者：
Kakko, S;Päivänsalo, M;Savolainen, MJ
通讯作者：
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