Functional assessment of prefrontal lobes in patients with major depression disorder using a dual-mode technique of 3D-arterial spin labeling and (18)F-fluorodeoxyglucose positron emission tomography/computed tomography.
Functional assessment of prefrontal lobes in patients with major depression disorder using a dual-mode technique of 3D-arterial spin labeling and (18)F-fluorodeoxyglucose positron emission tomography/computed tomography.
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DOI：
10.3892/etm.2017.4594
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发表时间：
2017-08
影响因子：
2.7
通讯作者：
Xu J
中科院分区：
文献类型：
--
作者：
Fu C;Shi D;Gao Y;Xu J
本研究旨在探讨重度抑郁症（MDD）患者前额叶脑血流灌注和糖代谢功能，并分析这些功能变化与抑郁症状的相关性。对17例MDD患者和16例静息状态的健康对照成功进行了3d动脉自旋标记（ASL）和18f -氟脱氧葡萄糖（FDG）正电子发射断层扫描/计算机断层扫描（PET/CT）。将患者的抑郁症状分为7个因素，用汉密尔顿抑郁评定量表进行评分。采用双样本t检验分别比较患者与健康对照组全脑18F-FDG的区域脑血流量（CBF）值和标准化摄取值（SUV），采用Pearson相关分析评价脑前额叶区CBF和SUV与患者Hamilton评分的相关性。与对照组相比，MDD患者双侧额上回中、右上回区域CBF减少，双侧额上回、中下回区域SUV减少。CBF值与患者左中额回和右中额回Hamilton总分呈正相关。suv与左中额回和右中额回汉密尔顿总分之间也存在正相关。与3D-ASL相比，18F-FDG PET/CT在识别前额叶功能异常方面更为敏感。前额叶CBF和SUV的减少与Hamilton评分密切相关。左额中回可能是MDD的一个关键功能区域。
The aim of this study was to explore the functions of cerebral blood perfusion and glucose metabolism in the prefrontal lobe of patients with major depression disorder (MDD), and to analyze the correlations between these functional changes and depressive symptoms. 3D-arterial spin labeling (ASL) and 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) were successfully performed in 17 patients with MDD and 16 healthy controls in a resting state. The depressive symptoms of the patients were classified into seven factors and scored with the Hamilton Depression Rating Scale. Regional cerebral blood flow (CBF) values and standardized uptake values (SUV) of 18F-FDG in the whole brain were respectively compared between the patients and healthy controls using a two-sample t-test, and the correlations between the CBF and SUV in the prefrontal cerebral regions with the patients' Hamilton scores were evaluated using Pearson correlation analysis. Decreased regional CBF was indicated in the bilateral middle and the right superior frontal gyri, and decreased regional SUV was indicated in the bilateral superior, middle and inferior frontal gyri in the MDD patients compared with the controls. Positive correlations were observed between CBF values and aggregate Hamilton scores in the left middle and right middle frontal gyri of the patients. Positive correlations were also observed between SUVs and aggregate Hamilton scores in the left middle and right middle frontal gyri. 18F-FDG PET/CT was indicated to be more sensitive than 3D-ASL in identifying the functional abnormalities in the prefrontal lobe. Decreased CBF and SUV in the prefrontal lobe were closely correlated with Hamilton score. The left middle frontal gyrus may be a key functional region in MDD.
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