Genes and Dietary Fatty Acids in Regulation of Fatty Acid Composition of Plasma and Erythrocyte Membranes.
Genes and Dietary Fatty Acids in Regulation of Fatty Acid Composition of Plasma and Erythrocyte Membranes.
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DOI：
10.3390/nu10111785
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发表时间：
2018-11-16
期刊：
影响因子：
5.9
通讯作者：
Schwab U
中科院分区：
文献类型：
--
作者：
Lankinen M;Uusitupa M;Schwab U
膳食脂肪酸组成改变了某些组织的血浆脂质和细胞膜的脂肪酸组成。此外，许多其他因素（年龄，性别，种族，健康状况，基因和基因×饮食相互作用）影响细胞膜或血浆脂质室的脂肪酸组成。因此，了解可能改变血浆或组织脂肪酸组成的机制的复杂性是非常重要的。我们进行了广泛的文献调查基因×饮食相互作用的调节脂肪酸组成。大多数相关研究都是观察性研究，但也有一些干预性试验倾向于证实真正的相互作用存在。大多数研究涉及11号染色体上的去饱和酶簇（FADS 1，FADS 2）和延伸酶。我们预计，新的遗传变异正在被发现，与血浆或组织脂肪酸组成的遗传调控。这些信息对于了解膳食脂肪酸及其内源性代谢在某些慢性疾病发生中的作用有很大帮助。
The fatty acid compositions of plasma lipids and cell membranes of certain tissues are modified by dietary fatty acid composition. Furthermore, many other factors (age, sex, ethnicity, health status, genes, and gene × diet interactions) affect the fatty acid composition of cell membranes or plasma lipid compartments. Therefore, it is of great importance to understand the complexity of mechanisms that may modify fatty acid compositions of plasma or tissues. We carried out an extensive literature survey of gene × diet interaction in the regulation of fatty acid compositions. Most of the related studies have been observational studies, but there are also a few intervention trials that tend to confirm that true interactions exist. Most of the studies deal with the desaturase enzyme cluster (FADS1, FADS2) in chromosome 11 and elongase enzymes. We expect that new genetic variants are being found that are linked with the genetic regulation of plasma or tissue fatty acid composition. This information is of great help to understanding the contribution of dietary fatty acids and their endogenic metabolism to the development of some chronic diseases.
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影响因子：
15.9
作者：
BAIER, LJ;SACCHETTINI, JC;PROCHAZKA, M
通讯作者：
PROCHAZKA, M
影响因子：
3.5
作者：
Dorajoo, Rajkumar;Sun, Ye;Friedlander, Yechiel
通讯作者：
Friedlander, Yechiel
影响因子：
4.2
作者：
Dumont, Julie;Huybrechts, Inge;Dallongeville, Jean
通讯作者：
Dallongeville, Jean
DOI：
10.1038/oby.2001.91
发表时间：
2001-11-01
期刊：
OBESITY RESEARCH
影响因子：
--
作者：
Berthier, MT;Couillard, C;Vohl, MC
通讯作者：
Vohl, MC
影响因子：
4
作者：
Carta G;Murru E;Banni S;Manca C
通讯作者：
Manca C