Animal models of non-alcoholic fatty liver disease: current perspectives and recent advances.
Animal models of non-alcoholic fatty liver disease: current perspectives and recent advances.
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DOI：
10.1002/path.4829
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发表时间：
2017-01
影响因子：
7.3
通讯作者：
Yu, Jun
中科院分区：
文献类型：
--
作者：
Lau, Jennie Ka Ching;Zhang, Xiang;Yu, Jun
关键词：
非酒精性脂肪性肝病（NAFLD）是一种以肝细胞中过量脂质积聚为特征的连续疾病谱。NAFLD从简单的肝脏脂肪变性发展为非酒精性脂肪性肝炎，在更严重的情况下，发展为肝纤维化、肝硬化和肝细胞癌（HCC）。由于其在世界范围内的流行，已经开发了反映人类NAFLD每个阶段的组织病理学和病理生理学的各种动物模型。选择合适的动物模型仍然是该领域面临的关键问题之一。本文综述了NAFLD的组织病理学和发病机制的关键分析，NAFLD和NAFLD诱导的HCC的每个阶段最常用和最近开发的动物模型，不同动物模型中NAFLD实验发病机制的主要机制，以及通过使用动物模型发现的最近治疗靶点的简要总结。将来自人类疾病的数据与来自动物研究的数据相结合表明，尽管目前的动物模型为理解NAFLD发病机制和进展的特定阶段提供了关键指导，但仍有必要进行进一步研究，以开发更准确的模型，更好地模拟疾病谱，以便提供更多的机制理解和新型治疗方法的鉴定/测试。版权所有2016作者.病理学杂志由John Wiley & Sons Ltd代表大不列颠和爱尔兰病理学会出版。
Non‐alcoholic fatty liver disease (NAFLD) is a continuous spectrum of diseases characterized by excessive lipid accumulation in hepatocytes. NAFLD progresses from simple liver steatosis to non‐alcoholic steatohepatitis and, in more severe cases, to liver fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). Because of its growing worldwide prevalence, various animal models that mirror both the histopathology and the pathophysiology of each stage of human NAFLD have been developed. The selection of appropriate animal models continues to be one of the key questions faced in this field. This review presents a critical analysis of the histopathology and pathogenesis of NAFLD, the most frequently used and recently developed animal models for each stage of NAFLD and NAFLD‐induced HCC, the main mechanisms involved in the experimental pathogenesis of NAFLD in different animal models, and a brief summary of recent therapeutic targets found by the use of animal models. Integrating the data from human disease with those from animal studies indicates that, although current animal models provide critical guidance in understanding specific stages of NAFLD pathogenesis and progression, further research is necessary to develop more accurate models that better mimic the disease spectrum, in order to provide both increased mechanistic understanding and identification/testing of novel therapeutic approaches. © 2016 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland.
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