Calcium-Activated Chloride Channel ANO1/TMEM16A: Regulation of Expression and Signaling.
Calcium-Activated Chloride Channel ANO1/TMEM16A: Regulation of Expression and Signaling.
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钙激活氯离子通道ANO 1/TMEM 16 A：表达和信号调节。
DOI：
10.3389/fphys.2020.590262
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发表时间：
2020
影响因子：
4
通讯作者：
Dulin NO
中科院分区：
文献类型：
--
作者：
Dulin NO
Anoctamin-1（ANO 1），也称为TMEM 16 A，是钙激活氯离子通道的Anoctamin家族中研究最多的成员，具有多种细胞功能。ANO 1控制多种细胞功能，包括细胞增殖、存活、迁移、收缩、分泌和神经元兴奋。本文综述了ANO 1表达调控和ANO 1介导的细胞内信号转导的细胞机制。这包括控制ANO 1表达的刺激和机制，激活ANO 1的激动剂和过程，以及由ANO 1介导的信号转导。主要的结论是，这一领域是知之甚少，仍然高度争议，并需要广泛和严格的进一步调查。
Anoctamin-1 (ANO1), also known as TMEM16A, is the most studied member of anoctamin family of calcium-activated chloride channels with diverse cellular functions. ANO1 controls multiple cell functions including cell proliferation, survival, migration, contraction, secretion, and neuronal excitation. This review summarizes the current knowledge of the cellular mechanisms governing the regulation of ANO1 expression and of ANO1-mediated intracellular signaling. This includes the stimuli and mechanisms controlling ANO1 expression, agonists and processes that activate ANO1, and signal transduction mediated by ANO1. The major conclusion is that this field is poorly understood, remains highly controversial, and requires extensive and rigorous further investigation.
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影响因子：
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作者：
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通讯作者：
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DOI：
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