Fibrin glue as a drug delivery system.

Fibrin glue as a drug delivery system.
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纤维蛋白胶作为药物输送系统。

DOI:
10.1016/j.jconrel.2010.06.025
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发表时间:
2010-11-20
期刊:
Journal of controlled release : official journal of the Controlled Release Society
影响因子:
--
通讯作者:
Mikos AG
Mikos AG
中科院分区:
其他
文献类型:
--
作者:
Spicer PP;Mikos AG

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止血胶在外科手术中用于止血和密封已有数十年的历史。它也被研究为细胞递送的凝胶和药物递送的载体。纤维蛋白胶的药物递送应用涵盖组织工程到化学疗法,并且涉及药物基质相互作用和释放动力学控制的几种机制。另外,药物或因子可以通过浸渍和通过共价键或基于亲和力的系统栓系到凝胶中而加载到凝胶中。本文综述了近年来纤维蛋白胶作为药物载体的研究进展。
Fibrin glue has been used surgically for decades for hemostasis as well as a sealant. It has also been researched as both a gel for cell delivery and a vehicle for drug delivery. The drug delivery applications for fibrin glue span tissue engineering to chemotherapy and involve several mechanisms for drug matrix interactions and control of release kinetics. Additionally, drugs or factors can be loaded in the gel via impregnation and tethering to the gel through covalent linkages or affinity based systems. This review highlights recent research of fibrin glue as a drug delivery vehicle.
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