Elevated ApoB/ApoA-I ratio is associated with acute anti-N-Methyl-D-aspartate receptor encephalitis, but not disease outcomes.
Elevated ApoB/ApoA-I ratio is associated with acute anti-N-Methyl-D-aspartate receptor encephalitis, but not disease outcomes.
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DOI：
10.3389/fneur.2022.896656
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发表时间：
2022
影响因子：
3.4
通讯作者：
Chen, Xiaohong
中科院分区：
文献类型：
--
作者：
Liu, Yingying;Ma, Xiaomeng;Ma, Lili;Su, Zhumin;Li, Donghong;Chen, Xiaohong
关键词：
本研究的目的是阐明载脂蛋白B100/载脂蛋白A-I（ApoB/ApoA-I）比值与抗N-甲基-D-天冬氨酸受体（抗NMDAR）脑炎之间的关系。本研究共纳入71例抗NMDAR脑炎患者，对其基线和随访时的ApoB/ApoA-I比值进行回顾性分析。抗 NMDAR 脑炎患者的 ApoB/ApoA-I 比值与基线改良 Rankin 量表 (mRS) 评分 >3 密切相关。亚组分析显示高 ApoB/ApoA-I 比值组和低 ApoB/ApoA-I 比值组之间存在明显差异。 ApoB/ApoA-I 比值与重症监护病房 (ICU) 治疗、住院时间、基线 mRS 评分、C 反应蛋白 (CRP) 和红细胞沉降率 (ESR) 呈正相关。高ApoB/ApoA-I组和低ApoB/ApoA-I组的比值在随访中均有所改善。 ApoB/ApoA-I 比率增加与急性抗 NMDAR 脑炎相关，但与疾病结果无关。血清ApoB/ApoA-I比值与外周血炎症和免疫相关。该研究结果可能为进一步探讨抗NMDAR脑炎的发病机制和治疗提供新思路。
The purpose of the present study is to clarify the relationship between the apolipoprotein B100/apolipoprotein A-I (ApoB/ApoA-I) ratio and anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis. A total of 71 patients with anti-NMDAR encephalitis were included in this study, and their ApoB/ApoA-I ratios in baseline and follow-up were retrospectively analyzed. The ApoB/ApoA-I ratio was closely correlated with the baseline-modified Rankin scale (mRS) score of >3 in patients with anti-NMDAR encephalitis. A subgroup analysis showed obvious differences between the high and low ApoB/ApoA-I ratio groups. The ApoB/ApoA-I ratio was positively correlated with intensive care unit (ICU) treatment, length of hospital stay, baseline mRS score, C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR). The ratios of the high and low ApoB/ApoA-I groups both improved in the follow-up. The increased ApoB/ApoA-I ratio is associated with acute anti-NMDAR encephalitis, but not disease outcomes. Serum ApoB/ApoA-I ratio was related to inflammation and immunity in peripheral blood. The findings might provide a new idea for further exploration of the pathogenesis and treatment of anti-NMDAR encephalitis.
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影响因子：
4.6
作者：
Ding M;Wennberg A;Ek S;Santoni G;Gigante B;Walldius G;Hammar N;Modig K
通讯作者：
Modig K
影响因子：
3.9
作者：
Agca, Rabia;Heslinga, Maaike;Nurmohamed, Michael T.
通讯作者：
Nurmohamed, Michael T.
影响因子：
11.1
作者：
Marcovina, S;Packard, CJ
通讯作者：
Packard, CJ
DOI：
10.1016/s1474-4422(15)00401-9
发表时间：
2016-04
期刊：
The Lancet. Neurology
影响因子：
--
作者：
Graus F;Titulaer MJ;Balu R;Benseler S;Bien CG;Cellucci T;Cortese I;Dale RC;Gelfand JM;Geschwind M;Glaser CA;Honnorat J;Höftberger R;Iizuka T;Irani SR;Lancaster E;Leypoldt F;Prüss H;Rae-Grant A;Reindl M;Rosenfeld MR;Rostásy K;Saiz A;Venkatesan A;Vincent A;Wandinger KP;Waters P;Dalmau J
通讯作者：
Dalmau J
影响因子：
48
作者：
Dalmau, Josep;Gleichman, Amy J.;Hughes, Ethen G.;Rossi, Jeffrey E.;Peng, Xiaoyu;Lai, Meizan;Dessain, Scott K.;Rosenfeld, Mynna R.;Balice-Gordon, Rita;Lynch, David R.
通讯作者：
Lynch, David R.