The association of apolipoproteins with later-life all-cause and cardiovascular mortality: a population-based study stratified by age.
The association of apolipoproteins with later-life all-cause and cardiovascular mortality: a population-based study stratified by age.
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DOI：
10.1038/s41598-021-03959-5
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发表时间：
2021-12-24
影响因子：
4.6
通讯作者：
Modig K
中科院分区：
文献类型：
--
作者：
Ding M;Wennberg A;Ek S;Santoni G;Gigante B;Walldius G;Hammar N;Modig K
中年血脂水平是心血管疾病的重要预测因素，但其与老年人死亡率的关系尚不清楚。我们的目的是（1）利用聚类分析确定基于胆固醇、甘油三酯和载脂蛋白的血脂谱，以及（2）研究不同年龄的血脂谱和血脂水平如何与晚年全因死亡率和心血管死亡率相关。我们使用了瑞典 AMORIS 队列中 98,270 名个体的数据，这些人在 1985 年至 1996 年间进行了血液测量，并随访至 2012 年。在随访期间（平均 18.0 年），有 30,730 人 (31.3%) 死亡。确定了三种脂质谱。与参考资料相比，39-59 岁或 60-79 岁的高血脂资料（低 ApoA-I 和高总胆固醇 (TC)、甘油三酯、ApoB 和 ApoB/ApoA-I 比率）与较高的全因死亡率相关。然而，≥80 岁的高血脂并不会导致更高的死亡率。对于特定标志物，高 TC (≥ 7.25 mmol/L) 与 39-59 岁的较高全因死亡率相关，但与 60-79 岁和 ≥ 80 岁的死亡率较低相关。另一方面，低 ApoA-I (< 1.28 g/L) 和高 ApoB/ApoA-I 比值 (≥ 1.18) 与较高的心血管死亡率相关，无论血脂测量的年龄，强调了它们对年轻人和老年人生存的潜在相关性。
Midlife lipid levels are important predictors of cardiovascular diseases, yet their association with mortality in older adults is less clear. We aimed to (1) identify lipid profiles based on cholesterol, triglycerides, and apolipoproteins using cluster analysis, and (2) investigate how lipid profiles and lipid levels at different ages are associated with later-life all-cause and cardiovascular mortality. We used data from 98,270 individuals in the Swedish AMORIS cohort who had blood measurements between 1985–1996 and were followed until 2012. Over the follow-up (mean 18.0 years), 30,730 (31.3%) individuals died. Three lipid profiles were identified. Compared with reference profile, a high lipid profile (low ApoA-I and high total cholesterol (TC), triglycerides, ApoB, and ApoB/ApoA-I ratio) at ages 39–59 or 60–79 was associated with higher all-cause mortality. A high lipid profile at ≥ 80 years, however, did not confer higher mortality. For the specific markers, high TC (≥ 7.25 mmol/L) was associated with higher all-cause mortality in ages 39–59 but lower mortality in ages 60–79 and ≥ 80. Low ApoA-I (< 1.28 g/L) and high ApoB/ApoA-I ratio (≥ 1.18), on the other hand, were associated with higher cardiovascular mortality regardless of age at lipid measurement, highlighting their potential relevance for survival in both young and older individuals.
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DOI：
10.1016/s0140-6736(20)32332-1
发表时间：
2020-11-21
期刊：
Lancet (London, England)
影响因子：
--
作者：
Gencer B;Marston NA;Im K;Cannon CP;Sever P;Keech A;Braunwald E;Giugliano RP;Sabatine MS
通讯作者：
Sabatine MS
影响因子：
9.9
作者：
Rist, Pamela M.;Buring, Julie E.;Rexrode, Kathryn M.
通讯作者：
Rexrode, Kathryn M.
影响因子：
2.1
作者：
Bathum L;Depont Christensen R;Engers Pedersen L;Lyngsie Pedersen P;Larsen J;Nexøe J
通讯作者：
Nexøe J
影响因子：
--
作者：
KRONMAL, RA;CAIN, KC;OMENN, GS
通讯作者：
OMENN, GS
影响因子：
168.9
作者：
Schatz, IJ;Masaki, K;Curb, JD
通讯作者：
Curb, JD