Roles of Heat Shock Proteins in Apoptosis, Oxidative Stress, Human Inflammatory Diseases, and Cancer.
Roles of Heat Shock Proteins in Apoptosis, Oxidative Stress, Human Inflammatory Diseases, and Cancer.
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DOI：
10.3390/ph11010002
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发表时间：
2017-12-23
期刊：
影响因子：
--
通讯作者：
Kappo AP
中科院分区：
文献类型：
--
作者：
Ikwegbue PC;Masamba P;Oyinloye BE;Kappo AP
热休克蛋白（Heat shock proteins，HSPs）通过启动蛋白质的折叠、修复、错误折叠的多肽的重折叠以及可能的不可修复蛋白的降解，在病理条件下发挥细胞保护作用。由活性氧（ROS）细胞水平增加和随后的炎症反应放大引起的过度凋亡在几种人类炎症性疾病（HID）和癌症的发病机制和进展中是众所周知的。在正常生理条件下，活性氧水平和炎症反应会受到控制，以通过抗氧化机制对抗感染原的细胞益处;然而，这种平衡在病理条件下可能会被破坏，从而导致氧化应激和大规模细胞破坏。因此，很明显，氧化剂-凋亡-炎症之间的相互作用在抗氧化系统的功能障碍中至关重要，最重要的是，在HID的进展中。因此，需要在人体中的氧化剂-抗氧化剂炎症状态之间保持谨慎的平衡。已知热休克蛋白通过抑制促炎因子来调节导致ROS内源性产生和内源性凋亡的炎症级联反应的作用，从而在HID和癌症的发病机制中起关键作用。我们建议，在HID和癌症中仔细诱导HSP，特别是在炎症之前，将为HID和癌症的管理和治疗提供良好的治疗方法。
Heat shock proteins (HSPs) play cytoprotective activities under pathological conditions through the initiation of protein folding, repair, refolding of misfolded peptides, and possible degradation of irreparable proteins. Excessive apoptosis, resulting from increased reactive oxygen species (ROS) cellular levels and subsequent amplified inflammatory reactions, is well known in the pathogenesis and progression of several human inflammatory diseases (HIDs) and cancer. Under normal physiological conditions, ROS levels and inflammatory reactions are kept in check for the cellular benefits of fighting off infectious agents through antioxidant mechanisms; however, this balance can be disrupted under pathological conditions, thus leading to oxidative stress and massive cellular destruction. Therefore, it becomes apparent that the interplay between oxidant-apoptosis-inflammation is critical in the dysfunction of the antioxidant system and, most importantly, in the progression of HIDs. Hence, there is a need to maintain careful balance between the oxidant-antioxidant inflammatory status in the human body. HSPs are known to modulate the effects of inflammation cascades leading to the endogenous generation of ROS and intrinsic apoptosis through inhibition of pro-inflammatory factors, thereby playing crucial roles in the pathogenesis of HIDs and cancer. We propose that careful induction of HSPs in HIDs and cancer, especially prior to inflammation, will provide good therapeutics in the management and treatment of HIDs and cancer.
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影响因子：
3.8
作者：
De Maio, Antonio
通讯作者：
De Maio, Antonio
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1.9
作者：
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DOI：
10.1084/jem.181.3.943
发表时间：
1995-03-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
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通讯作者：
van Eden W
影响因子：
15.9
作者：
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