Influenza A and B Virus-Triggered Epithelial-Mesenchymal Transition Is Relevant to the Binding Ability of NA to Latent TGF-β.
Influenza A and B Virus-Triggered Epithelial-Mesenchymal Transition Is Relevant to the Binding Ability of NA to Latent TGF-β.
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甲型和B型流感病毒引发的上皮-间充质转化与NA与潜在TGF-β的结合能力有关
DOI：
10.3389/fmicb.2022.841462
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发表时间：
2022
影响因子：
5.2
通讯作者：
Sun L
中科院分区：
文献类型：
--
作者：
Yang W;Bai X;Li H;Li H;Fan W;Zhang H;Liu W;Sun L
Epithelial–mesenchymal transition (EMT) is an important mechanism of lung tissue repair after injury, but excessive EMT may lead to pulmonary fibrosis, respiratory failure, and even death. The EMT triggered by influenza A virus (IAV) and influenza B virus (IBV) is not well understood. We hypothesized that there was difference in EMT induced by different influenza virus strains. Here we discovered that both IAV [A/WSN/1933 (H1N1), WSN] and IBV (B/Yamagata/16/88, Yamagata) infection caused EMT in mouse lung and A549 cells, and more EMT-related genes were detected in mice and cells infected with WSN than those infected with Yamagata. Neuraminidase (NA) of IAV is able to activate latent TGF-β and the downstream TGF-β signaling pathway, which play a vital role in EMT. We observed that IAV (WSN) triggered more activated TGF-β expression and stronger TGF-β/smad2 signaling pathway than IBV (Yamagata). Most importantly, WSN NA combined more latent TGF-β than Yamagata NA in A549 cells. Collectively, these data demonstrate that both IAV and IBV induce TGF-β/smad2 signaling pathway to promote EMT, which might depend on the binding ability of NA to latent TGF-β.
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影响因子：
5.8
作者：
Qiao J;Zhang M;Bi J;Wang X;Deng G;He G;Luan Z;Lv N;Xu T;Zhao L
通讯作者：
Zhao L
DOI：
10.1146/annurev-pathol-020712-163930
发表时间：
2013-01-24
期刊：
Annual review of pathology
影响因子：
--
作者：
Duffield JS;Lupher M;Thannickal VJ;Wynn TA
通讯作者：
Wynn TA
DOI：
10.1186/s13046-020-01690-z
发表时间：
2020-11-05
期刊：
Journal of experimental & clinical cancer research : CR
影响因子：
--
作者：
Tang Q;Chen J;Di Z;Yuan W;Zhou Z;Liu Z;Han S;Liu Y;Ying G;Shu X;Di M
通讯作者：
Di M
影响因子：
7.3
作者：
Gonzalez DM;Medici D
通讯作者：
Medici D
影响因子：
6.7
作者：
Carlson CM;Turpin EA;Moser LA;O'Brien KB;Cline TD;Jones JC;Tumpey TM;Katz JM;Kelley LA;Gauldie J;Schultz-Cherry S
通讯作者：
Schultz-Cherry S