Traditional Medicine Collection Tracking System (TM-CTS): a database for ethnobotanically driven drug-discovery programs.
Traditional Medicine Collection Tracking System (TM-CTS): a database for ethnobotanically driven drug-discovery programs.
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DOI：
10.1016/j.jep.2011.03.029
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发表时间：
2011-05-17
影响因子：
5.4
通讯作者：
Eisenberg, David M.
中科院分区：
文献类型：
--
作者：
Harris, Eric S. J.;Erickson, Sean D.;Tolopko, Andrew N.;Cao, Shugeng;Craycroft, Jane A.;Scholten, Robert;Fu, Yanling;Wang, Wenquan;Liu, Yong;Zhao, Zhongzhen;Clardy, Jon;Shamu, Caroline E.;Eisenberg, David M.
民族植物学驱动的药物发现计划包括与植物药物制备的许多方面有关的数据，从最初的植物采集到化学提取和分级。传统药材采集跟踪系统(TM-CTS)的创建是为了组织和存储这类数据，用于一个国际合作项目，该项目涉及对常用中药植物进行系统评估。该系统是使用域驱动设计技术开发的，并使用Java、Hibernate、PostgreSQL、商业智能和报告工具(BIRT)和ApacheTomcat来实现。TM-CTS关系数据库模式包含70多种数据类型，包括500多个数据字段。该系统结合了一些在民族植物学项目中有用的独特功能，例如支持有关植物采集、加工方法、按照现有药典标准对植物进行质量测试、化学提取和分级以及植物的历史用途等信息。该数据库还容纳了以多种语言提供的数据，并与为支持基于高通量筛选的药物发现工作而建立的数据库系统进行了整合。它是通过一个基于Web的应用程序访问的，该应用程序提供了广泛的多格式报告功能。这个新的数据库系统是为了支持一个评估中药植物生物活性的项目而设计的。用于创建数据库的软件是开源的，免费提供，并可能应用于其他民族植物学驱动的天然产品收集和药物发现计划。
Ethnobotanically-driven drug-discovery programs include data related to many aspects of the preparation of botanical medicines, from initial plant collection to chemical extraction and fractionation. The Traditional Medicine-Collection Tracking System (TM-CTS) was created to organize and store data of this type for an international collaborative project involving the systematic evaluation of commonly used Traditional Chinese Medicinal plants. The system was developed using domain-driven design techniques, and is implemented using Java, Hibernate, PostgreSQL, Business Intelligence and Reporting Tools (BIRT), and Apache Tomcat. The TM-CTS relational database schema contains over 70 data types, comprising over 500 data fields. The system incorporates a number of unique features that are useful in the context of ethnobotanical projects such as support for information about botanical collection, method of processing, quality tests for plants with existing pharmacopoeia standards, chemical extraction and fractionation, and historical uses of the plants. The database also accommodates data provided in multiple languages and integration with a database system built to support high throughput screening based drug discovery efforts. It is accessed via a web-based application that provides extensive, multi-format reporting capabilities. This new database system was designed to support a project evaluating the bioactivity of Chinese medicinal plants. The software used to create the database is open source, freely available, and could potentially be applied to other ethnobotanically-driven natural product collection and drug-discovery programs.
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DOI：
10.1073/pnas.0905845106
发表时间：
2009-02-24
影响因子：
11.1
作者：
Awano, Tomoyuki;Johnson, Gary S.;Coates, Joan R.
通讯作者：
Coates, Joan R.
影响因子：
1.6
作者：
Binns, SE;Arnason, JT;Baum, BR
通讯作者：
Baum, BR
影响因子：
3.4
作者：
Eisenberg, David M.;Harris, Eric S. J.;Littlefield, Bruce A.;Cao, Shugeng;Craycroft, Jane A.;Scholten, Robert;Bayliss, Peter;Fu, Yanling;Wang, Wenquan;Qiao, Yanjiang;Zhao, Zhongzhen;Chen, Hubiao;Liu, Yong;Kaptchuk, Ted;Hahn, William C.;Wang, Xiaoxing;Roberts, Thomas;Shamu, Caroline E.;Clardy, Jon
通讯作者：
Clardy, Jon
影响因子：
4.3
作者：
Hildreth, Jana;Hrabeta-Robinson, Eva;Miller, James
通讯作者：
Miller, James
影响因子：
3
作者：
Tolopko AN;Sullivan JP;Erickson SD;Wrobel D;Chiang SL;Rudnicki K;Rudnicki S;Nale J;Selfors LM;Greenhouse D;Muhlich JL;Shamu CE
通讯作者：
Shamu CE