Effects of static magnetic fields on plasma levels of angiotensin II and aldosterone associated with arterial blood pressure in genetically hypertensive rats
Effects of static magnetic fields on plasma levels of angiotensin II and aldosterone associated with arterial blood pressure in genetically hypertensive rats
复制标题
静磁场对遗传性高血压大鼠血浆血管紧张素II和醛固酮水平与动脉血压的影响
作者：
H. Okano;C. Ohkubo
本研究采用7周龄的抗卒中自发性高血压大鼠（SHR），观察了静磁场（SMF）对SHR高血压形成的影响。SHR被随机分配到两个不同的暴露组或未暴露组。暴露组的SHR持续暴露于3.0- 10.0mT和8.0- 25.0mT两种不同类型的外磁场12周。SMF由连接到大鼠笼的永磁板产生。采用间接尾套法每周测定一次每只大鼠的血压（BP）。与未暴露组相比，SMFs抑制和延缓了两个暴露组中高血压的发展，达到了统计学显著的程度，持续数周。降压作用与SHR血浆血管紧张素II和醛固酮水平的降低程度有关。这些结果表明，具有空间梯度的mT强度的SMF可以归因于通过激素调节系统抑制早期BP升高。Bioelectromagnetics 24：403-412，2003.© 2003 Wiley利斯公司
Effects of static magnetic fields (SMFs) on development of hypertension were investigated using young male, stroke resistant, spontaneously hypertensive rats (SHRs) beginning at 7 weeks of age. SHRs were randomly assigned to two different exposure groups or an unexposed group. The SHRs in the exposure groups were constantly exposed to two different types of external SMFs of 3.0–10.0 mT or 8.0–25.0 mT for 12 weeks. The SMFs were generated from permanent magnetic plates attached to the rat cage. The blood pressure (BP) of each rat was determined at weekly intervals using indirect tail‐cuff method. The SMFs suppressed and retarded the development of hypertension in both exposed groups to a statistically significant extent for several weeks, as compared with an unexposed group. The antipressor effects were related to the extent of reduction in plasma levels of angiotensin II and aldosterone in the SHRs. These results suggest that the SMFs of mT intensities with spatial gradients could be attributable to suppression of early BP elevation via hormonal regulatory system. Bioelectromagnetics 24:403–412, 2003. © 2003 Wiley‐Liss, Inc.
影响因子：
2.5
作者：
Kangarlu, A;Burgess, RE;Robitaille, PML
通讯作者：
Robitaille, PML
影响因子：
3.4
作者：
Rosen, AD
通讯作者：
Rosen, AD
DOI：
10.1089/107555301300004538
发表时间：
2001-02-01
影响因子：
2.6
作者：
Alfano, AP;Taylor, AG;Gillies, GT
通讯作者：
Gillies, GT