Olfactory receptor 5B21 drives breast cancer metastasis.
Olfactory receptor 5B21 drives breast cancer metastasis.
复制标题
嗅觉受体5B21促进乳腺癌转移。
DOI：
10.1016/j.isci.2021.103519
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发表时间：
2021-12-17
期刊：
影响因子：
5.8
通讯作者：
Tannous BA
中科院分区：
文献类型：
--
作者：
Li M;Schweiger MW;Ryan DJ;Nakano I;Carvalho LA;Tannous BA
嗅觉受体（ORs）负责嗅觉，在鼻上皮外的各种生理过程中发挥重要作用，包括癌症。然而，在乳腺癌中，ORs的表达和功能仍未得到充分研究。我们研究了OR转录物丰度在原发性和转移性乳腺癌中对脑、骨和肺的重要性。尽管20个OR转录本在远处转移中有差异表达，但与原发肿瘤相比，OR5B21在所有三个转移部位的转录本丰度均有所增加。OR5B21基因敲低可显著降低乳腺癌细胞的侵袭迁移和向不同器官尤其是脑的转移，而OR5B21转录物丰度的增加则具有相反的作用。从机制上讲，OR5B21的表达通过STAT3/NF-κB/CEBPβ信号轴与上皮细胞向间质细胞的转化有关。我们提出OR5B21（以及潜在的其他or）作为一种新的致癌基因，有助于乳腺癌转移和辅助治疗的潜在靶点。OR5B21在人乳腺癌MDA-MB-231转移细胞中的过表达OR5B21调节乳腺癌细胞的侵袭和迁移能力OR5B21敲低可降低乳腺癌转移OR5B21通过STAT3/NFκB/CEBPβ信号轴诱导EMT；细胞生物学;癌症
Olfactory receptors (ORs), responsible for the sense of smell, play an essential role in various physiological processes outside the nasal epithelium, including cancer. In breast cancer, however, the expression and function of ORs remain understudied. We examined the significance of OR transcript abundance in primary and metastatic breast cancer to the brain, bone, and lung. Although 20 OR transcripts were differentially expressed in distant metastases, OR5B21 displayed an increased transcript abundance in all three metastatic sites compared with the primary tumor. Knockdown of OR5B21 significantly decreased the invasion and migration of breast cancer cells as well as metastasis to different organs especially the brain, whereas increasing of OR5B21 transcript abundance had the opposite effect. Mechanistically, OR5B21 expression was associated with epithelial to mesenchymal transition through the STAT3/NF-κB/CEBPβ signaling axis. We propose OR5B21 (and potentially other ORs) as a novel oncogene contributing to breast cancer metastasis and a potential target for adjuvant therapy. OR5B21 overexpress in human breast cancer MDA-MB-231 metastatic cells OR5B21 regulates invasion and migration ability of breast cancer cells Knockdown of OR5B21 decreases breast cancer metastasis OR5B21 induces EMT via the STAT3/NFκB/CEBPβ signaling axis Classification Description: Molecular biology; Cell biology; Cancer
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人髓质白血病中异位表达的嗅觉受体2AT4的功能表征。
影响因子：
7
作者：
Manteniotis S;Wojcik S;Brauhoff P;Möllmann M;Petersen L;Göthert JR;Schmiegel W;Dührsen U;Gisselmann G;Hatt H
通讯作者：
Hatt H
影响因子：
6.6
作者：
Kalbe, Benjamin;Schulz, Viola Maria;Hatt, Hanns
通讯作者：
Hatt, Hanns
影响因子：
3.7
作者：
Matsueda S;Wang M;Weng J;Li Y;Yin B;Zou J;Li Q;Zhao W;Peng W;Legras X;Loo C;Wang RF;Wang HY
通讯作者：
Wang HY
DOI：
10.1002/advs.202002015
发表时间：
2020-11
期刊：
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
影响因子：
--
作者：
Azam Z;To ST;Tannous BA
通讯作者：
Tannous BA
影响因子：
254.7
作者：
DeSantis, Carol E.;Fedewa, Stacey A.;Jemal, Ahmedin
通讯作者：
Jemal, Ahmedin