A glial signal consisting of gliomedin and NrCAM clusters axonal Na+ channels during the formation of nodes of Ranvier.
A glial signal consisting of gliomedin and NrCAM clusters axonal Na+ channels during the formation of nodes of Ranvier.
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DOI：
10.1016/j.neuron.2010.02.004
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发表时间：
2010-02-25
期刊：
影响因子：
16.2
通讯作者：
Peles, Elior
中科院分区：
文献类型：
--
作者：
Feinberg, Konstantin;Eshed-Eisenbach, Yael;Frechter, Shahar;Amor, Veronique;Salomon, Daniela;Sabanay, Helena;Dupree, Jeffrey L.;Grumet, Martin;Brophy, Peter J.;Shrager, Peter;Peles, Elior
跳跃性传导需要Na+通道在郎维尔结处的高密度积聚。周围神经系统中的结Na+通道簇通过未知机制由髓鞘化雪旺细胞调节。在发育过程中，Na+通道首先聚集在与每个髓鞘段相邻的半节点处，然后聚集在由两个半节点融合形成的成熟节点中。在这里，我们表明，在heminodes的Na+通道的初始集群需要神经胶质细胞NrCAM和gliomedin，以及它们的轴突受体神经成束蛋白186（NF 186）。我们进一步证明，heminodal集群与第二，paranodal连接（PNJ）依赖的机制，允许Na+通道积累在成熟的节点，限制其分布在两个不断增长的髓鞘节间。我们建议，雪旺氏细胞组装节点的朗维尔通过捕获Na+通道在heminodes和约束其分布的节点间隙。这两种合作机制共同确保了有髓鞘神经中快速有效的传导。
Saltatory conduction requires high-density accumulation of Na+ channels at the nodes of Ranvier. Nodal Na+ channel clustering in the peripheral nervous system is regulated by myelinating Schwann cells through unknown mechanisms. During development, Na+ channels are first clustered at heminodes that border each myelin segment, and later in the mature nodes that are formed by the fusion of two heminodes. Here we show that initial clustering of Na+ channels at heminodes requires glial NrCAM and gliomedin, as well as their axonal receptor neurofascin 186 (NF186). We further demonstrate that heminodal clustering coincides with a second, paranodal junction (PNJ)-dependent mechanism that allows Na+ channels to accumulate at mature nodes by restricting their distribution between two growing myelin internodes. We propose that Schwann cells assemble the nodes of Ranvier by capturing Na+ channels at heminodes and by constraining their distribution to the nodal gap. Together, these two cooperating mechanisms ensure fast and efficient conduction in myelinated nerves.
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DOI：
10.1023/a:1007053411667
发表时间：
1999-04-01
期刊：
JOURNAL OF NEUROCYTOLOGY
影响因子：
--
作者：
Ching, W;Zanazzi, G;Salzer, JL
通讯作者：
Salzer, JL
影响因子：
7.8
作者：
Dupree, J L;Girault, J A;Popko, B
通讯作者：
Popko, B
DOI：
10.1523/jneurosci.5225-09.2010
发表时间：
2010-02-17
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Horresh I;Bar V;Kissil JL;Peles E
通讯作者：
Peles E
DOI：
10.1083/jcb.200110003
发表时间：
2002-01-21
期刊：
The Journal of cell biology
影响因子：
--
作者：
Komada M;Soriano P
通讯作者：
Soriano P
影响因子：
16.2
作者：
Eshed, Y;Feinberg, K;Peles, E
通讯作者：
Peles, E