Oxytocin and vasopressin secretion in response to stimuli producing learned taste aversions in rats.

Oxytocin and vasopressin secretion in response to stimuli producing learned taste aversions in rats.
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催产素和加压素的分泌响应刺激,产生大鼠习得性味觉厌恶。

DOI:
10.1037//0735-7044.100.4.466
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发表时间:
1986
影响因子:
1.9
通讯作者:
Stricker,EM
Stricker,EM
中科院分区:
医学4区
文献类型:
--
作者:
Verbalis,JG;McHale,CM;Gardiner,TW;Stricker,EM

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给大鼠注射氯化锂、硫酸铜和阿扑吗啡都会刺激催产素 (OT) 的分泌,并且在较小程度上刺激精氨酸加压素的分泌。这些药物被认为会引起老鼠的内脏疾病,因为它们能有效促进习得性味觉厌恶的获得。当腹腔注射而不是静脉注射时,CuSO 4 对血浆OT水平有更大的影响,而LiCl则没有,结果表明LiCl可能通过中枢化学感受器激活来刺激OT分泌,而CuSO 4 主要通过局部腹膜刺激起作用。尚未发现循环 OT 在习得性味觉厌恶中的因果作用。这些和其他发现表明,外周 OT 水平可能代表大鼠内脏疾病的可量化标志,因此可能有助于解释产生习得性味觉厌恶的行为研究,前提是不存在其他神经垂体分泌刺激。
Administration of lithium chloride, copper sulfate, and apomorphine to rats each stimulated the secretion of oxytocin (OT) and, to a much lesser degree, arginine vasopressin. These agents are assumed to cause visceral illness in rats because of their effectiveness in promoting the acquisition of learned taste aversions. CuSO 4 had a greater effect on plasma OT levels when administered ip rather than iv, whereas LiCl did not, results suggesting that LiCl probably stimulates OT secretion by central chemoreceptor activation whereas CuSO 4 acts predominantly by local peritoneal irritation. A causal role for circulating OT in the acquisition of learned taste aversions was not found. These and other findings suggest that peripheral levels of OT may represent a quantifiable marker of visceral illness in rats and therefore might be useful in the interpretation of behavioral studies in which learned taste aversions are produced, provided that other stimuli of neurohypophyseal secretion are absent.
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