Diazoxide promotes oligodendrocyte differentiation in neonatal brain in normoxia and chronic sublethal hypoxia.
Diazoxide promotes oligodendrocyte differentiation in neonatal brain in normoxia and chronic sublethal hypoxia.
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DOI：
10.1016/j.brainres.2014.08.046
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发表时间：
2014-10-24
期刊：
影响因子：
2.9
通讯作者：
Rivkees, Scott A.
中科院分区：
文献类型：
--
作者：
Zhu, Ying;Wendler, Christopher C.;Shi, Olivia;Rivkees, Scott A.
脑室周围白色物质损伤（PWMI）是早产儿脑损伤最常见的原因。据信，晚期少突胶质细胞祖细胞（OPC）的丢失和少突胶质细胞成熟的破坏有助于PWMI中髓鞘形成的缺陷。目前，尚无临床批准的药物可用于治疗PWMI。以前，我们发现二氮嗪促进髓鞘形成和减轻慢性亚致死性缺氧模型PWMI的脑损伤。在这项研究中，我们研究了二氮嗪促进髓鞘形成的机制。我们观察到，二氮嗪增加分化少突胶质细胞在大脑白色物质的比例，促进分化相关的转录因子Nkx 2.2和Sox 10的表达，并增加髓鞘基因CNP和MBP的表达。这些结果表明，二氮嗪促进发育中的大脑中的少突胶质细胞分化。
Periventricular white matter injury (PWMI) is the most common cause of brain injury in preterm infants. It is believed that loss of late oligodendrocyte progenitor cells (OPCs) and disrupted maturation of oligodendrocytes contributes to defective myelination in PWMI. At present, no clinically approved drugs are available for treating PWMI. Previously, we found that diazoxide promotes myelination and attenuates brain injury in the chronic sublethal hypoxia model of PWMI. In this study, we investigated the mechanisms by which diazoxide promotes myelination. We observed that diazoxide increases the ratio of differentiated oligodendrocytes in the cerebral white matter, promotes the expression of differentiation-associated transcriptional factors Nkx2.2 and Sox10, and increases the expression of myelin genes CNP and MBP. These results show that diazoxide promotes oligodendrocyte differentiation in the developing brain.
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影响因子：
3.6
作者：
Borch, K;Greisen, G
通讯作者：
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DOI：
10.1016/j.ijdevneu.2009.05.009
发表时间：
2009-12
期刊：
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience
影响因子：
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发表时间：
2003-02-15
期刊：
JOURNAL OF NEUROBIOLOGY
影响因子：
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作者：
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通讯作者：
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