Modeling premature brain injury and recovery.
Modeling premature brain injury and recovery.
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DOI：
10.1016/j.ijdevneu.2009.05.009
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发表时间：
2009-12
期刊：
影响因子：
--
通讯作者：
Vaccarino FM
中科院分区：
文献类型：
--
作者：
Scafidi J;Fagel DM;Ment LR;Vaccarino FM
早产是一个日益严重的公共卫生问题，因为大量婴儿幸存后留下了脑损伤造成的神经发育后遗症。神经影像学的最新进展表明，尽管一些神经解剖结构发生了改变，但其他结构会随着时间的推移而改善。这篇综述概述了对学龄早产儿大脑结构和功能以及相关动物模型的最新见解。这些动物模型为科学家提供了深入探索损伤的分子和细胞机制以及大脑恢复潜力的机会。还概述了大脑对于神经发生和胶质细胞生成的内源性潜力，以及环境如何促进恢复。这些临床前模型将为了解导致不同程度损伤和恢复的遗传和表观遗传机制提供重要见解，从而允许探索靶向治疗以促进发育中的早产大脑的恢复。
Premature birth is a growing and significant public health problem because of the large number of infants that survive with neurodevelopmental sequelae from brain injury. Recent advances in neuroimaging have shown that although some neuroanatomical structures are altered, others improve over time. This review outlines recent insights into brain structure and function in these preterm infants at school age and relevant animal models. These animal models have provided scientists with an opportunity to explore in depth the molecular and cellular mechanisms of injury as well as the potential of the brain for recovery. The endogenous potential that the brain has for neurogenesis and gliogenesis, and how environment contributes to recovery, are also outlined. These preclinical models will provide important insights into the genetic and epigenetic mechanisms responsible for variable degrees of injury and recovery, permitting the exploration of targeted therapies to facilitate recovery in the developing preterm brain.
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