A Prospective Study of Obesity, Metabolic Health, and Cancer Mortality.
A Prospective Study of Obesity, Metabolic Health, and Cancer Mortality.
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DOI：
10.1002/oby.22067
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发表时间：
2018-01
期刊：
影响因子：
--
通讯作者：
Gilchrist SC
中科院分区：
文献类型：
--
作者：
Akinyemiju T;Moore JX;Pisu M;Judd SE;Goodman M;Shikany JM;Howard VJ;Safford M;Gilchrist SC
我们研究了代谢健康状况是否会增加癌症死亡率的风险，以及这种关联是否因体重指数（BMI）类别而异。我们对来自卒中地理和种族差异原因（REGARDS）队列的22，514名参与者进行了前瞻性研究。我们将代谢不健康状态定义为具有以下3项以上：1）空腹血糖升高，2）高甘油三酯，3）血脂异常，4）高血压，5）腰围增加。我们将参与者分为正常体重（BMI：18.5-24.9 kg/m2）、超重（BMI 25.0-29.9 kg/m2）和肥胖（BMI ≥ 30 kg/m2）组。我们进行了考克斯比例风险回归来估计随访期间癌症死亡率的风险比（HR）和95%置信区间（CI）。在体重正常的参与者中，与代谢健康的参与者相比，代谢不健康的参与者癌症死亡风险增加（HR：1.57; 95% CI：1.15 - 2.16）。对于代谢不健康和体重正常的参与者，肥胖相关癌症的总体死亡风险更高（HR：2.31，95% CI：1.13 - 4.73）。与正常体重的参与者相比，代谢健康的超重者任何癌症死亡率的风险降低（校正的HR：0.79，95% CI：0.63-0.98）。在代谢不健康的正常体重参与者中，总体和肥胖相关癌症死亡率的风险增加。
We examined whether metabolic health status increases the risk of cancer mortality, and whether this association varied by body mass index (BMI) category. We performed a prospective study of 22,514 participants from the REasons for Geographic and Racial Differences in Stroke (REGARDS) cohort. We defined metabolic unhealthy status as having 3+ of the following: 1) elevated fasting glucose, 2) high triglycerides, 3) dyslipidemia, 4) hypertension, and 5) elevated waist circumference. We categorized participants into normal weight (BMI: 18.5-24.9 kg/m2), overweight (BMI 25.0-29.9 kg/m2) and obese (BMI ≥ 30 kg/m2) groups. We performed Cox proportional hazards regression to estimate hazards ratios (HRs) and 95% confidence intervals (CIs) for cancer mortality during follow-up. Among participants with normal weight, those who were metabolically unhealthy had increased risk of cancer mortality (HR: 1.57; 95% CI: 1.15 – 2.16) compared with metabolically healthy participants. Overall mortality risk for participants who were metabolically unhealthy and normal-weight was stronger for obesity-related cancers (HR: 2.31, 95% CI: 1.13 – 4.73). Compared with participants with normal weight, those who were metabolically healthy overweight were at reduced risk of any cancer mortality (adjusted HR: 0.79, 95% CI: 0.63-0.98). There was an increased risk of overall- and obesity-related- cancer mortality among metabolically unhealthy normal weight participants.
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DOI：
10.1093/annonc/mdu042
发表时间：
2014-10
期刊：
Annals of oncology : official journal of the European Society for Medical Oncology
影响因子：
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作者：
Chan DSM;Vieira AR;Aune D;Bandera EV;Greenwood DC;McTiernan A;Navarro Rosenblatt D;Thune I;Vieira R;Norat T
通讯作者：
Norat T
代谢健康降低了弗雷明汉研究成年人中与肥胖相关癌症的风险。
DOI：
10.1158/1055-9965.epi-14-0240
发表时间：
2014-10
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Moore LL;Chadid S;Singer MR;Kreger BE;Denis GV
通讯作者：
Denis GV
影响因子：
5.3
作者：
Liu, Jiankang;Musani, Solomon K.;Fox, Caroline S.
通讯作者：
Fox, Caroline S.
影响因子：
7.1
作者：
Chandler, Paulette D.;Song, Yiqing;Wang, Lu
通讯作者：
Wang, Lu
影响因子：
--
作者：
Oh, Chang-Mo;Jun, Jae Kwan;Suh, Mina
通讯作者：
Suh, Mina