Host genetic factors determining COVID-19 susceptibility and severity.
Host genetic factors determining COVID-19 susceptibility and severity.
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DOI：
10.1016/j.ebiom.2021.103629
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发表时间：
2021-10
期刊：
影响因子：
11.1
通讯作者：
Meyer CG
中科院分区：
文献类型：
--
作者：
Velavan TP;Pallerla SR;Rüter J;Augustin Y;Kremsner PG;Krishna S;Meyer CG
由严重急性呼吸系统综合症冠状病毒-2 (SARS-CoV-2) 引起的 COVID-19 大流行给人类带来了前所未有的挑战。 SARS-CoV-2 感染范围从无症状到严重的 COVID-19 病程，包括急性呼吸窘迫综合征 (ARDS)、多器官受累和死亡。疾病严重程度的危险因素包括年龄较大、男性、体重指数增加和已有的合并症。种族也与 COVID-19 的易感性和严重程度有关。现在人们越来越认识到宿主对 COVID-19 的遗传易感性，并且已经进行了有关 COVID-19 易感性的全基因组和候选基因关联研究。与炎症或免疫反应相关的基因中的几种常见和罕见变异已被识别。我们总结了有关 COVID-19 宿主遗传学的研究，并汇编了与 COVID-19 易感性和疾病严重程度相关的遗传变异。我们讨论了应该进一步研究的候选基因，以了解这种关联，并提供与发病机制、风险分类、治疗反应、精准医学和药物再利用相关的见解。
The COVID-19 pandemic caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) poses an unprecedented challenge to humanity. SARS-CoV-2 infections range from asymptomatic to severe courses of COVID-19 with acute respiratory distress syndrome (ARDS), multiorgan involvement and death. Risk factors for disease severity include older age, male sex, increased BMI and pre-existing comorbidities. Ethnicity is also relevant to COVID-19 susceptibility and severity. Host genetic predisposition to COVID-19 is now increasingly recognized and whole genome and candidate gene association studies regarding COVID-19 susceptibility have been performed. Several common and rare variants in genes related to inflammation or immune responses have been identified. We summarize research on COVID-19 host genetics and compile genetic variants associated with susceptibility to COVID-19 and disease severity. We discuss candidate genes that should be investigated further to understand such associations and provide insights relevant to pathogenesis, risk classification, therapy response, precision medicine, and drug repurposing.
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DOI：
10.1007/s00018-021-03889-5
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期刊：
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影响因子：
--
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