In vivo functional imaging of intrinsic scattering changes in the human retina with high-speed ultrahigh resolution OCT.
In vivo functional imaging of intrinsic scattering changes in the human retina with high-speed ultrahigh resolution OCT.
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DOI：
10.1364/oe.17.003861
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发表时间：
2009-03-02
期刊：
影响因子：
3.8
通讯作者：
Fujimoto JG
中科院分区：
文献类型：
--
作者：
Srinivasan VJ;Chen Y;Duker JS;Fujimoto JG
探测视网膜功能的非侵入性方法对于视网膜疾病的早期检测是有意义的。虽然传统上视网膜功能是直接测量与视网膜电图（ERG），最近功能性光学成像的视网膜已被证明。在这份手稿中，刺激诱导的，内在的光学散射的变化，在人体视网膜在体内测量高速，100分辨率光学相干断层扫描（OCT），每秒50,000轴向扫描和1003.3微米的轴向分辨率。描述了能够测量功能性OCT视网膜信号的刺激和测量协议。光感受器中的OCT信号变化被证明。两个不同的响应具有不同的时间和空间特性的报告。这些结果进行了讨论的背景下，以前在视网膜中测量的光学固有信号眼底成像和扫描激光检眼镜。最后，在人类受试者体内功能视网膜成像相关的挑战进行了讨论。
Non-invasive methods of probing retinal function are of interest for the early detection of retinal disease. While retinal function is traditionally directly measured with the electroretinogram (ERG), recently functional optical imaging of the retina has been demonstrated. In this manuscript, stimulus-induced, intrinsic optical scattering changes in the human retina are measured in vivo with high-speed, ultrahigh resolution optical coherence tomography (OCT) operating at 50,000 axial scans per second and ∼3.3 micron axial resolution. A stimulus and measurement protocol that enables measurement of functional OCT retinal signals is described. OCT signal changes in the photoreceptors are demonstrated. Two distinct responses having different temporal and spatial properties are reported. These results are discussed in the context of optical intrinsic signals measured previously in the retina by fundus imaging and scanning laser ophthalmoscopy. Finally, challenges associated with in vivo functional retinal imaging in human subjects are discussed.
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